+-Associate Director / Director, Information Technology
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Operations team reporting to the Chief Financial Officer, the Associate Director / Director of Information Technology (IT) will develop and lead the strategic direction of Accent’s IT operations, ensuring the delivery of efficient and effective technology services throughout the organization. This key role will oversee all IT operations, managing IT infrastructure and resources to meet organizational needs, and will be responsible for working cross-functionally to identify long-term, scalable, practical solutions as the organization grows. The ideal candidate will be a trusted IT advisor with the ability to translate function-specific needs into a dynamic IT roadmap and strategy.
Responsibilities:
- Create and manage an IT roadmap and strategy that aligns with business goals and objectives;
- Partner cross-functionally to facilitate business needs definition, workflow design, and integration of scientific processes and technology into effective IT solutions;
- Establish efficiency and efficacy standards, providing recommendations for improvement of IT infrastructure and systems;
- Establish priorities for systems design and implementation to develop new and/or modify the company’s information processing systems;
- Drive contingency planning and IT security and compliance, including by developing and implementing IT policies and processes and leading IT-related compliance efforts;
- Oversee and manage security of all systems, networks, and enterprise information;
- Direct onsite IT support for Accent platforms, systems and infrastructure related needs or troubleshooting;
- Develop and manage relationships with external IT vendors and service providers; assess and onboard new providers as needed
Qualifications and skills:
- 7+ years of experience in IT management, preferably in a combination of public and entrepreneurial environments;
- Outstanding business partnering experience, including strong communication and listening skills;
- Excellent organizational and analytical skills and ability to multi-task in an extremely fast-paced environment;
- Proficient in latest technology and best practices for IT systems and management;
- Demonstrated capability in building IT functions that enable the business through strategic support and decision making;
- Prior experience in:
- evaluating, implementing, and managing scientific data management platforms, cloud computing (AWS), on-site storage solutions, and IT vendor services;
- administering onsite and cloud enterprise data and collaboration tools, including Exchange, AWS, Oracle, and SharePoint;
- managing both Windows and Linux computers in a mixed scientific, technical and business computing environment, using centralized management tools;
- working with (or understanding of) LIMS (scientific informatics systems) is a plus/preferred;
- Background in pharmaceutical, biotech or other life science companies is preferred;
- Bachelors degree in Computer Science or relevant field required
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Manager / Senior Manager, Informatics
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Operations team reporting to the Senior Manager of Research Operations, the Informatics Manager will manage, support, and develop our research informatics and data management platforms. The Informatics Manager will actively collaborate cross-functionally to lead the development and evolution of the informatics platform to support Accent’s continued growth.
Responsibilities:
- Oversee informatics infrastructure by managing, upgrading, and coordinating service across all of Accent’s SaaS (Software as a Service) platforms;
- Design, implement and document system configurations for new and existing informatics system implementation, including sample management, results analysis, lab workflow, release & stability management, electronic lab notebooks (ELN) etc.;
- Collaborate with key internal and external stakeholders, including internal scientists in the DMPK, Biology, Molecular Discovery, and Chemistry teams to support and enhance informatics platforms;
- Coordinate software needs of internal groups with SaaS providers and work with SaaS providers in future product design and improvement (e.g., automation of processes such as data capture and registration);
- Negotiate and coordinate the renewal of SaaS provider and consultant contracts annually;
- Support weekly registration activities of compounds and biologics;
- Conduct system testing prior to new feature releases; coordinate new user training and host quarterly informatics user group sessions;
- Assist users with creating new protocols, assays, dashboards, queries, etc. in the ELN and other data analysis/visualization platforms;
- Assist with system support, maintenance, and administration of lab equipment, such as:
- Robotic liquid handlers from TECAN and Agilent Technologies
- Readers from PerkinElmer, BMG Labtech, etc.
Qualifications:
- M.S. with at least 3+ years of industry experience in research informatics, data management, data engineering; or Bachelor’s degree with 4+ years of experience;
- Experience in implementing a major, commercial SaaS LIMS product preferred;
- Working knowledge of biology, biophysics, chemistry, and preclinical data;
- Working knowledge of Windows and Linux operating systems;
- Experience with REST API and Amazon Web Services (AWS) Research compute environment is preferred;
- Excellent organizational skills and ability to multi-task in an extremely fast-paced environment;
- Working knowledge of AGILE principles is a plus;
- Strong communication, interpersonal and collaboration skills in order to successfully partner with internal and external stakeholders;
- Solid analytical and problem-solving abilities
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Associate Director / Director, Protein and Structural Sciences
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
The Head of Protein and Structural Sciences is responsible for leading an internal team to support structure-based efforts, biophysical experiments, and protein production for the diverse targets within the company pipeline. The successful candidate will use internal resources and CRO capabilities as well as collaborate with cross-functional teams to progress Accent programs. This position reports to the Vice President of Molecular Discovery.
Responsibilities:
- Manage an internal team of biophysicists and structural biologists to find creative solutions to challenges that enable program progression from target validation through development candidate selection
- Lead all aspects of experimental structure-based drug design efforts including construct design, protein production, crystallization, and structure determination utilizing an experimental outsourcing model and internal team members
- Analysis of proprietary and public structural information to positively impact computational and medicinal chemistry efforts
- Manage protein production efforts for biochemical assays, biophysical methods, high throughput screening, and structural biology activities through collaboration with internal and external scientists
- Effectively communicate complex information to internal and external audiences
- Establish relationships, manage contracts, and oversee activities at partner CROs
Qualifications and skills:
- PhD in Structural Biology, Biophysics, Biochemistry, or a closely related field plus at least 10 years of industry experience or the equivalent expertise
- Experience in managing and mentoring multiple direct reports
- Deep expertise in protein crystallization and X-ray structure determination of protein-ligand complexes and a track record of utilizing structure-based methods to positively impact drug discovery projects; success with fragment-based drug discovery highly desirable
- Extensive knowledge of protein structure and function, with the ability to communicate complex information to a broad audience
- Demonstrated competency in protein construct design as well as expression and purification strategies
- Experience with other structural and biophysical techniques (e.g. computational modeling, EM, SAXS, NMR, SPR, ITC) is preferred
- Experience with outsourcing desired
- A track record of innovation and scientific rigor
- Demonstrated leadership on project teams (Project or Department/Discipline lead) and/or in matrixed organizations is desired
- Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude, motivated by a desire to offer cancer patients novel therapies that extend and improve their lives
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Administrative Assistant
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
The Administrative Assistant will be responsible for providing support to members of Accent’s Executive Team and will report into the Senior Manager, Operations & Administration. This role requires excellent organization skills, demonstrated attention to detail and commitment to confidentiality. Additionally, the successful candidate must be able to interact professionally with all levels and functions within the company, as well as external partners, potential collaborators, and vendors. This role will need to work efficiently and collaboratively in a fast-paced environment.
Responsibilities:
- Provide logistical planning and administrative support including calendar management, meeting coordination, travel arrangements, and expense reporting for members of the Executive Team
- Manage team calendars and schedules in an efficient and highly organized manner
- Plan and prepare for meetings and off-sites, including reserving meeting rooms, setting up catering, working with external sites and vendors as needed
- Coordinate interview schedules for external candidates and onboarding schedules for new employees as needed
- Assist in creating and formatting documents, correspondences, presentations, and other written materials
- Assist with on-site needs such as coordinating visitors and receiving deliveries as needed
Qualifications and skills:
- 4+ years of experience as an administrative assistant or equivalent
- Excellent interpersonal and communication skills (written, verbal, and presentation) including ability to communicate throughout all levels of an organization
- Strong organizational skills and attention to detail with a sense of urgency and flexibility to adapt to changing and competing priorities
- Strong working knowledge of Microsoft Office Suites is expected, with a proficiency in Microsoft Outlook
- Experience in biotechnology preferred
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited
+-Director, Intellectual Property
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017 and named as one of Fortune’s 50 Top Ten Workplaces in Healthcare and Biopharma and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
Reporting to the Chief Financial Officer, the Director of Intellectual Property will play a key strategic role in architecting and managing the Company’s intellectual property strategy and portfolio. This key role will direct and oversee all intellectual property matters, working with outside counsel and internal team members to strategically evaluate intellectual property opportunities; prepare, review, file, and prosecute patent applications; and monitor patent, regulatory and competitive landscapes. The ideal candidate will be a trusted advisor and business partner with the ability to identify and align strategic opportunities to critical business objectives.
Responsibilities:
- Develop and execute creative and thoughtful strategies to protect the company’s intellectual property;
- Work closely with R&D teams to build strong patent portfolios around key assets to ensure long-term competitive advantage by identifying and evaluating new inventions, conducting prior art searches, managing new and existing patent portfolios, and responding to administrative challenges instituted by third parties;
- Identify, monitor and analyze competitive intellectual property and potential freedom-to-operate matters;
- Manage outside counsel on worldwide patent prosecution and maintenance and work with outside counsel to draft and prosecute the company’s patent applications;
- Review proposed publications and presentations for potential disclosure issues;
- Provide advice and cross-functional support for R&D, business development, alliance management, project teams and other functional areas through all phases of research and development;
- Working with management, prepare, negotiate, and review contracts and agreements;
- Support IP due diligence and agreement review/negotiation related to partnering activities;
- Educate and advise colleagues on IP processes and best practices;
- Work with the executive leadership team to implement and administer IP policies and best practices
Qualifications and skills:
- 5+ years of experience practicing intellectual property law, with an emphasis on small molecule patent prosecution, at a large law firm and/or in-house legal department;
- Registered to practice before the U.S. Patent and Trademark Office;
- J.D. from an accredited law school;
- Thorough understanding of U.S. patent law and familiar with foreign patent laws in major countries;
- Excellent interpersonal, communication and presentation skills, including ability to communicate complex issues clearly and succinctly;
- Ability to think strategically with a broad perspective;
- Strong organizational skills, including careful attention to detail and ability to manage and prioritize multiple matters simultaneously and to respond to rapidly shifting priorities in ambiguous or challenging situations;
- Ability to work collaboratively as a business partner and to recognize and respond quickly, clearly and pragmatically to urgent situations and opportunities;
- Ph.D. or other advanced degree in organic chemistry or chemical sciences preferred
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Principal Research Associate / Scientist, Biophysics
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
The Principal Research Associate / Scientist, Biophysics will be part of Accent’s Molecular Discovery team, reporting into the Principal Scientist, Biophysics. The ideal candidate will bring deep experience in small-molecule Surface Plasmon Resonance (SPR) assay development and prosecution to support drugging strategy development and lead discovery across the entire portfolio. This role will collaborate across functions, in a fast-paced and exciting environment.
Responsibilities:
- Execute small molecule, protein, and RNA interaction studies using SPR, with an emphasis on KD determination and mechanism of action elucidation (i.e. binding competition, allostery, ternary complex formation)
- Develop robust Biacore assays for incorporation into our external drug discovery screening cascades
- Collaborate with chemistry and biology colleagues to contribute progress towards project goals
- Participate in meetings to identify and solve problems, communicate on-going work and progress, and plan forward thinking strategies
- Make intellectual contributions to diverse aspects of hit finding and lead discovery
Qualifications and skills:
- Bachelor and Master’s degree in related discipline required; PhD and relevant industry experience preferred
- Experience with biophysical methods (such as SPR, BLI, MST, ITC, or DSF) is required
- Experience in developing Biacore methods to assess protein-small molecule or protein-protein interactions with consistent, high-quality data analysis and troubleshooting is preferred
- Ability to balance multiple projects at different hit triage stages
- Exceptional communication skills, and ability to effectively present data
- Demonstrated ability to work effectively within cross-functional teams to deliver project goals within timelines
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Research Associate / Senior Research Associate, Biology
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017 and named as one of Fortune’s 50 Best Small Workplaces in 2019 and a Fierce15 biotech company in 2020, Accent is building a highly collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Biology team, this Research Associate or Senior Research Associate will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of epitranscriptomics in human disease, and progress the Accent pipeline.
Responsibilities:
- Execute cell and molecular biology studies to investigate the role of novel epitranscriptomic pathways in human disease;
- Assist with the development of cell-based assays to be used in support of medicinal chemistry efforts and structure activity relationship assessment;
- Maintain good written records of laboratory procedures, results and conclusions.
Qualifications:
- BS/MS in Biology or related field with 1-2 years of relevant industry experience or the equivalent expertise;
- Proficiency with mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
- Knowledge of laboratory automation a plus;
- Excellent organizational and communication skills;
- Ability to design and execute experiments, analyze and document results as part of a fast-paced research team.
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Senior Research Associate / Principal Research Associate, Biology
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017 and named as one of Fortune’s 50 Best Small Workplaces in 2019 and a Fierce15 biotech company in 2020, Accent is building a highly collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Biology team, this Senior or Principal Research Associate will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of epitranscriptomics in human disease, and progress the Accent pipeline.
Responsibilities:
- Execute cell and molecular biology studies to investigate the role of novel epitranscriptomic pathways in human disease;
- Assist with the development of cell-based assays to be used in support of medicinal chemistry efforts and structure activity relationship assessment;
- Maintain good written records of laboratory procedures, results and conclusions;
- Perform and report interim analysis of accumulated data to project teams and Accent leadership;
- Assist in the development of and compliance with all Accent policies and operational guidelines;
- Participate in various aspects of small company capability building.
Qualifications:
- BS/MS in Biology or related field with a minimum of 3+ years relevant industry experience or the equivalent expertise;
- Proficiency with mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
- Ability to design and execute experiments, analyze and document results as part of a fast-paced research team;
- Knowledge of laboratory automation a plus;
- Excellent organizational and communication skills
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-HR Generalist
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Operations team reporting to the Head of People, the HR Generalist will help recruit, retain, and develop Accent’s employees in support of its mission to build promising new therapies for cancer. The HR Generalist will actively collaborate cross-functionally across the organization and contribute to the growth and evolution of the People department and the broader organization.
Responsibilities:
- Support the Head of People with strategic HR initiatives and projects, including but not limited to:
- Talent management and succession planning
- Performance management
- Rewards and recognition
- Employee engagement
- Learning and development
- Annual headcount and organizational planning;
- Manage day-to-day HR activities, including employee inquiries on HR policies and processes;
- Partner across the Operations team to assist in implementation and ongoing oversight of an HRIS platform;
- Manage benefits administration, including planning for and executing open enrollment and managing employee benefits needs throughout the plan year;
- Oversee recruiting and onboarding of new Accent employees: manage open positions, work with recruiting agencies, coordinate interview days, develop and extend offers and work cross-functionally to create a positive onboarding experience.
Qualifications and skills:
- Bachelor’s degree in business or Human Resources required;
- 3-5 years of Human Resources experience; life sciences or biotech industry experience preferred;
- Knowledge of HR processes, policies, and procedures;
- Excellent communication skills and ability to effectively collaborate with others in a team environment;
- Attention to detail and ability to prioritize and take action based on needs of the business;
- Motivated self-starter that can work independently and proactively to address employee and business needs;
- Aptitude for process improvement, desire to drive efficiencies and learn the business holistically;
- Comfortable working in a fast-paced, evolving, start-up environment;
- Proficiency in MS Office, particularly PowerPoint.
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Scientist / Senior Scientist, Biology
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Biology team, the Scientist/Sr. Scientist candidate will report into a Principal Scientist/Project Leader to join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team. This position will elucidate the role of RNA-modifying targets in human cancer and disease, with the potential to work on novel drug targets and ultimately progress late-stage Discovery projects into clinical development.
Responsibilities:
- Independently design and execute experiments focused on the validation of new RNA-modifying drug targets to elucidate mechanism of action and target dependency of small molecule inhibitors within cancer indications;
- Act as a key member of a cross-functional project team, working collaboratively and efficiently to progress targets towards clinical development;
- Manage external CRO projects and services;
- Proactively review literature to bring in newest scientific findings, ideas, and methods/technologies for discovery research; and
- Interpret, summarize, and present research findings to project teams, Accent leadership and collaborators.
Qualifications:
- A PhD in Molecular Biology, Cancer Biology, or a related field plus at least 2 years post-degree experience; or a minimum of 8-10 years of industry experience with BS/MS
- Extensive experience in mammalian tissue culture (including si/shRNA, CRISPR, lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR, microscopy, flow cytometry);
- Knowledge of cancer biology and related signaling-pathways, and ability to critically evaluate relevant literature;
- Evidence of creative thinking and problem solving, confidently applying novel strategies and tools to address key questions quickly and efficiently;
- Capability to work within a dynamic matrix environment, with strong contribution to project progression;
- Excellent organizational and communication skills;
- Strong publication record relevant to cancer biology is a plus; and
- Experience working with and managing projects at CROs is a plus.
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Head of Biology
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
The Head of Biology will oversee and direct all aspects of discovery and preclinical biology, including target discovery and validation, assay development and in vitro and in vivo biology related activities. This role will actively collaborate across the organization, partnering with Molecular Discovery, Chemistry and Translational Medicine, to advance and expand Accent’s drug discovery pipeline. As a member of the Executive Team, this role will also contribute to setting the Company’s overall scientific plan as well as the Company’s broader strategic direction.
Responsibilities:
- Lead the Biology team in the development of actionable targets; apply deep knowledge of cancer biology to execute scientifically rigorous strategies to inform drug discovery, development, and programmatic decision making through all phases of development;
- Partner with research and project teams to drive candidate go/no-go decisions and development prioritization;
- Manage the Biology organization by developing and leading talented scientists;
- Oversee CRO selection, mentorship, and activities, build external consultant networks and set the balance of internal versus external capabilities;
- Demonstrate drive, visibility, and influence in key Company decisions as a member of the Executive Team, including critical portfolio and programmatic decisions;
- Set department goals and milestones aligned to corporate objectives; communicate scientific findings and drug discovery strategy and plans to external stakeholders, e.g., the Board of Directors, potential investors, and our strategic partners.
Qualifications and skills:
- Ph.D. (or equivalent) in Biology or closely allied field with 10+ years of relevant oncology drug discovery and development experience in biotech or pharma;
- In-depth knowledge of cancer biology and the mechanistic pharmacology of diverse oncology therapeutics; evidenced by a strong publication record;
- Proven experience in developing small molecule drug discovery programs, from target identification through IND filing;
- Strong history of leading, and developing a high functioning Biology research team;
- Experience working with and managing CROs is a plus;
- Outstanding interpersonal and communication skills, both written and oral, including ability to communicate complex information succinctly;
- Excellent analytical and problem-solving skills, and ability to manage multiple projects and initiatives simultaneously in a fast-paced environment.
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
