+-Senior / Principal Research Associate, Biology
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Biology team, this Senior or Principal Research Associate will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of RNA modification in human disease, and progress the Accent pipeline.
Responsibilities:
- Execute cell and molecular biology studies to investigate the role of novel epitranscriptomic pathways in human disease;
- Assist with the development of cell-based assays to be used in support of medicinal chemistry efforts and structure activity relationship assessment;
- Maintain good written records of laboratory procedures, results and conclusions;
- Perform and report interim analysis of accumulated data to project teams and Accent leadership;
- Assist in the development of and compliance with all Accent policies and operational guidelines;
- Participate in various aspects of small company capability building
Qualifications:
- BS/MS in Biology or related field with a minimum of 3+ years relevant industry experience or the equivalent expertise;
- Proficiency with mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
- Ability to design and execute experiments, analyze and document results as part of a fast-paced research team;
- Knowledge of laboratory automation a plus;
- Excellent organizational and communication skills
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Scientist / Senior Scientist, Medicinal Chemistry
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Medicinal Chemistry team, this Scientist or Senior Scientist will help oversee the advancement of Accent’s drug discovery pipeline. She or he will collaborate cross-functionally with our internal and external teams to analyze data, understand structure-activity relationships, design chemical matter and work with our external synthetic chemistry partners to deliver these compounds to progress multiple drug discovery programs.
Responsibilities:
- Lead and direct the design and synthesis of chemical matter for a key program utilizing an outsourcing model
- Develop and implement synthetic sequences to access chemical matter and troubleshoot synthetic issues as they arise
- Interpret data from various sources and carry out integrated structure-activity relationship analysis to support the design of new chemical matter to optimize biochemical and cell potency, selectivity, pharmacokinetic properties and in vivoefficacy
- Deliver and present high-quality data to diverse audiences (e.g., cross-functional project teams, external partners)
Qualifications and skills:
- PhD in Organic Chemistry or related field with some industry experience or BS/MS with 4+ years of industry experience
- Familiarity with small molecule drug discovery approaches
- Ability to interpret data from diverse sources and design chemical matter that addresses liabilities and shortcomings
- A track record of problem solving
- Deep understanding of synthetic organic chemistry
- Effective communicator in program team settings
- Experience with multiple target classes and is a plus
- Prior experience in chemistry CRO management is a plus
- Experience in oncology is a plus
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Vice President, Translational Medicine
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
Reporting to the Chief Scientific Officer, the Vice President, Translational Medicine will develop and implement the translational medicine strategy while collaborating with an exceptional, cross-functional team of scientists and leading efforts to progress the Accent pipeline. This role will leverage deep experience with targeted cancer therapies and partner closely with the research, pre-clinical and clinical development teams to deliver robust, exploratory biomarker plans to support early clinical POC, patient selection and clinical development strategy. As a member of the Executive Team, the Vice President, Translational Medicine will also contribute to setting the Company’s overall scientific plan as well as the Company’s broader strategic direction.
Responsibilities:
- Lead all aspects of Translational Medicine strategy and operations, including development and implementation of a biomarker strategy for oncology-focused, novel precision small molecule therapies;
- Develop and execute scientifically rigorous strategies to inform drug discovery, development and regulatory decisions through all phases of drug development;
- Plan strategy and execute on development of biomarker plans including the development of companion diagnostic(s) (CDx), as needed;
- Work closely with project teams to identify and execute translational research opportunities to optimize indication selection, patient enrichment and pharmacodynamic biomarkers for use in future clinical trials;
- Partner with research and project teams to drive candidate go/no-go decisions and development prioritization;
- Contribute to the design execution of program translational strategies integrating both disease and pathway approaches;
- Demonstrate drive, visibility and influence in key Company decisions as a member of the Executive Team, including development candidate selection, patient dosage selection, clinical strategy, and regulatory filing strategy;
- Identify significant issues and risks that may impact overall project plans and initiate contingency plans as appropriate;
- Oversee CRO selection, mentorship, and activities, build external consultant networks and set the balance of internal versus external capabilities;
- Contribute to driving the shape of global regulatory filings including preparation of regulatory documentation and active participation in meetings with regulatory agencies
Qualifications and skills:
- PhD or equivalent degree and at least 10 years of biotech / pharma experience;
- In-depth knowledge of cancer biology and the mechanistic pharmacology of diverse oncology therapeutics;
- Proven experience designing and executing a preclinical biomarker strategy and transitioning and executing biomarker assays in the clinic;
- Documented experience designing and executing preclinical oncology drug combination studies and mechanism or resistance studies, in partnership with preclinical Cancer Biology team(s);
- Documented experience in oncology drug development, including contributions to multiple regulatory submissions;
- Knowledge of GCPs, ICH guidelines and FDA regulations and familiarity with EMA/CHMP regulations and guidelines, and other international regulatory requirements;
- Experience working with and managing CROs is a plus;
- Outstanding interpersonal and communication skills, both written and oral, including ability to communicate complex information succinctly;
- Excellent analytical and problem-solving skills, and ability to manage multiple projects and initiatives simultaneously in a fast-paced environment
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Associate Director / Director, Information Technology
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Operations team reporting to the Chief Financial Officer, the Associate Director / Director of Information Technology (IT) will develop and lead the strategic direction of Accent’s IT operations, ensuring the delivery of efficient and effective technology services throughout the organization. This key role will oversee all IT operations, managing IT infrastructure and resources to meet organizational needs, and will be responsible for working cross-functionally to identify long-term, scalable, practical solutions as the organization grows. The ideal candidate will be a trusted IT advisor with the ability to translate function-specific needs into a dynamic IT roadmap and strategy.
Responsibilities:
- Create and manage an IT roadmap and strategy that aligns with business goals and objectives;
- Partner cross-functionally to facilitate business needs definition, workflow design, and integration of scientific processes and technology into effective IT solutions;
- Establish efficiency and efficacy standards, providing recommendations for improvement of IT infrastructure and systems;
- Establish priorities for systems design and implementation to develop new and/or modify the company’s information processing systems;
- Drive contingency planning and IT security and compliance, including by developing and implementing IT policies and processes and leading IT-related compliance efforts;
- Oversee and manage security of all systems, networks, and enterprise information;
- Direct onsite IT support for Accent platforms, systems and infrastructure related needs or troubleshooting;
- Develop and manage relationships with external IT vendors and service providers; assess and onboard new providers as needed
Qualifications and skills:
- 7+ years of experience in IT management, preferably in a combination of public and entrepreneurial environments;
- Outstanding business partnering experience, including strong communication and listening skills;
- Excellent organizational and analytical skills and ability to multi-task in an extremely fast-paced environment;
- Proficient in latest technology and best practices for IT systems and management;
- Demonstrated capability in building IT functions that enable the business through strategic support and decision making;
- Prior experience in:
- evaluating, implementing, and managing scientific data management platforms, cloud computing (AWS), on-site storage solutions, and IT vendor services;
- administering onsite and cloud enterprise data and collaboration tools, including Exchange, AWS, Oracle, and SharePoint;
- managing both Windows and Linux computers in a mixed scientific, technical and business computing environment, using centralized management tools;
- working with (or understanding of) LIMS (scientific informatics systems) is a plus/preferred;
- Background in pharmaceutical, biotech or other life science companies is preferred;
- Bachelors degree in Computer Science or relevant field required
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Manager / Senior Manager, Informatics
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Operations team reporting to the Senior Manager of Research Operations, the Informatics Manager will manage, support, and develop our research informatics and data management platforms. The Informatics Manager will actively collaborate cross-functionally to lead the development and evolution of the informatics platform to support Accent’s continued growth.
Responsibilities:
- Oversee informatics infrastructure by managing, upgrading, and coordinating service across all of Accent’s SaaS (Software as a Service) platforms;
- Design, implement and document system configurations for new and existing informatics system implementation, including sample management, results analysis, lab workflow, release & stability management, electronic lab notebooks (ELN) etc.;
- Collaborate with key internal and external stakeholders, including internal scientists in the DMPK, Biology, Molecular Discovery, and Chemistry teams to support and enhance informatics platforms;
- Coordinate software needs of internal groups with SaaS providers and work with SaaS providers in future product design and improvement (e.g., automation of processes such as data capture and registration);
- Negotiate and coordinate the renewal of SaaS provider and consultant contracts annually;
- Support weekly registration activities of compounds and biologics;
- Conduct system testing prior to new feature releases; coordinate new user training and host quarterly informatics user group sessions;
- Assist users with creating new protocols, assays, dashboards, queries, etc. in the ELN and other data analysis/visualization platforms;
- Assist with system support, maintenance, and administration of lab equipment, such as:
- Robotic liquid handlers from TECAN and Agilent Technologies
- Readers from PerkinElmer, BMG Labtech, etc.
Qualifications:
- M.S. with at least 3+ years of industry experience in research informatics, data management, data engineering; or Bachelor’s degree with 4+ years of experience;
- Experience in implementing a major, commercial SaaS LIMS product preferred;
- Working knowledge of biology, biophysics, chemistry, and preclinical data;
- Working knowledge of Windows and Linux operating systems;
- Experience with REST API and Amazon Web Services (AWS) Research compute environment is preferred;
- Excellent organizational skills and ability to multi-task in an extremely fast-paced environment;
- Working knowledge of AGILE principles is a plus;
- Strong communication, interpersonal and collaboration skills in order to successfully partner with internal and external stakeholders;
- Solid analytical and problem-solving abilities
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Senior / Principal Scientist, Protein and Structural Sciences (Biophysics)
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Protein and Structural Sciences team, the Senior / Principal Scientist will play a critical and influential role in the application of biophysical methods in drug discovery. Reporting to the Director of Protein & Structural Sciences, the Senior / Principal Scientist will apply biophysical methods to understand small molecule-protein interactions and work cross-functionally with teams of internal and external scientists to utilize this expertise to provide insights that will advance Accent’s drug discovery programs.
Responsibilities:
- Design, execute, and analyze key Surface Plasmon Resonance (SPR) experiments for small molecule compound screening with a high level of independence to support hit finding, lead optimization and mechanism of inhibition studies;
- Maintain internal databases with latest results and contribute to optimization of LIMS systems for biophysical data;
- Effectively communicate biophysical information and results to a variety of audiences in multiple settings, including project teams and company management;
- Oversee activities at partner CROs producing biophysical data; and
- Establish and manage an internal SPR facility at Accent
Qualifications and Skills:
- PhD or experienced BS/MS in Biophysics, Biochemistry, Bioanalytical Chemistry or a closely related field;
- 2+ years laboratory experience using SPR spectroscopy, experience with Biacore platforms preferred;
- Extensive knowledge and experience with SPR and other biophysical techniques (including DSF, ITC, MST and NMR), with the ability to communicate complex information to a broad audience;
- Proficiency in operating and maintaining SPR systems and associated data processing packages;
- Demonstrated commitment to innovation and scientific rigor across multiple protein targets and superfamilies;
- Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude;
- Experience with outsourcing preferred;
- Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude, motivated by a desire to create the novel cancer therapeutics and the vision to offer cancer patients novel therapies that extend and improve their lives
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Laboratory Operations Assistant
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
The Laboratory Operations Assistant will work as part of the Research Operations team, reporting into the Laboratory Operations Coordinator, to support laboratory operations at Accent Therapeutics. This highly collaborative role will gain broad exposure to biotech laboratory processes and procedures, supporting the critical day-to-day operations that drive research and development at a preclinical biopharmaceutical company.
Responsibilities:
- Coordinate with Lab Operations team to ensure full coverage during hours of operation
- Receive hazardous and non-hazardous packages
- Coordinate deliveries with loading dock and delivery personnel
- Restock and maintain laboratory consumable and reagent inventory
- Ensure the proper storage and disposal of biological and chemical waste
- Perform daily, weekly, and monthly safety checks
- Assist in the maintenance of laboratory equipment
- Assist in routine quality control of biological samples and lab equipment
- Coordinate on-call rotation schedule with other Lab Operations team members as needed for coverage outside of standard business hours
Qualifications and skills:
- Entry level position; a high school diploma is required
- Attention to detail and strong organizational skills
- Ability to work independently
- Basic knowledge of laboratory safety protocols or experience in other restricted environments
- Familiarity with personal computers and Office 365 environment
- Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude
Position: Part-Time (20-30 hours/week)
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
