+-Scientist / Senior Scientist, Protein and Structural Sciences
Position Summary:
As a member of the Protein and Structural Sciences team, reporting to the Head of Protein and Structural Sciences, the Scientist or Senior Scientist will work with internal and external teams to execute structure-based efforts and protein production, utilizing his/her expertise to provide insights that will advance Accent’s drug discovery programs .
Responsibilities:
- Guide experimental structure-based drug design efforts including construct design, protein production, crystallization, and structure determination utilizing an outsourcing model
- Analyze proprietary and public structural information to positively impact computational and medicinal chemistry efforts
- Guide protein production efforts for biochemical and biophysical assays and structural biology activities through collaboration with internal and external scientists
- Characterize proteins utilizing experimental techniques, including Bioanalyzer, DSF, and enzymatic assays
- Provide regular updates to cross-functional teams and participate in structure-based compound design
Qualifications and skills:
- PhD in Structural Biology, Biophysics, Biochemistry or a closely related field
- Expertise in protein crystallization and X-ray structure determination
- Experience in protein crystallography within the pharmaceutical or biotechnology industry a plus
- Knowledge of protein structure and function, with the ability to communicate structural information to a broad audience
- Demonstrated competency in protein construct design as well as expression and purification strategies
- Excellent organizational and communication skills are essential
- Experience with biophysical techniques (DSF, ITC, MST, NMR, and/or SPR) is a plus
- Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Scientist / Senior Scientist, Biology
Position Summary:
As a key member of the Biology team, the Scientist or Senior Scientist will join a dynamic, enthusiastic, highly interdisciplinary and collaborative team to elucidate the role of RNA modification in human disease and progress the Accent pipeline.
Responsibilities:
- Independently design and execute experiments focused on the identification and validation of new RNA-modifying drug targets;
- Act as a key member of a cross-functional project team working collaboratively to progress targets through the Accent pipeline;
- Participate in the creation of biology strategy for novel targets;
- Proactively review literature to bring in newest scientific findings, ideas, and methods/technologies for discovery research; and
- Interpret, summarize and present research findings to project teams and Accent leadership
Qualifications:
- A PhD in Molecular Biology, Cancer Biology, or a related field plus at least 2 years post-degree experience; or a minimum of 8 years of industry experience with BS/MS
- Extensive experience in mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
- Knowledge of cancer biology and related signaling-pathways, and ability to critically evaluate relevant literature;
- Capability to work within a dynamic matrix environment, with strong contribution to project progression;
- Excellent organizational and communication skills;
- Experience working with and managing projects at CROs a plus
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Principal Scientist/Associate Director/Director, Medicinal Chemistry
Position Summary:
As a senior medicinal chemist reporting to the Head of Chemistry, this person will implement the medicinal chemistry strategy while collaborating with a cross-functional team of scientists and lead a team of external synthetic chemistry resources to progress multiple drug discovery programs.
Responsibilities:
- Co-lead interdisciplinary project teams and work with a team of scientists to progress projects from target selection and validation through candidate selection;
- Design and oversee synthesis of novel chemical entities aimed to optimize biochemical and cell potency, selectivity, pharmacokinetic properties and in vivo efficacy;
- Contribute to execution of IP strategy in collaboration with internal and external intellectual property attorneys;
- Oversee activities at partner CROs
Qualifications and skills:
- Ph.D. in synthetic organic chemistry or medicinal chemistry with a minimum of 7 years of medicinal chemistry experience in the pharmaceutical industry;
- Hands-on experience in successfully designing and synthesizing novel small molecule therapies;
- Extensive knowledge in the current practice and literature of synthetic and medicinal chemistry;
- Strong understanding of structure-based design, physicochemical properties, and DMPK;
- Experience with computational software, electronic notebooks and LIMS;
- Experience in co-leading discovery projects;
- Effective oral and written communication with peers and people in other functional areas;
- Ability to work independently and in a dynamic team environment;
- Knowledge and experience of fragment approaches and/or novel protein targets are desirable;
- Experience in screening and hit validation activities for enzymatic and binding assays is desirable;
- Experience in outsourcing and managing CROs is a plus;
- Experience in oncology is a plus
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Senior / Principal Scientist, Lead Discovery
Position Summary:
As a member of the Lead Discovery team, reporting to the Head of Lead Discovery, the Senior or Principal Scientist will develop and implement biochemical assays for internal and external use and collaborate with a cross-functional team of scientists to support drug discovery efforts across the Accent portfolio.
Responsibilities:
- Design and execution of biochemical assays for multiple novel target classes for use in screening and characterizing small molecule inhibitors;
- Analyze data, including curve fitting and IC50 calculations using state-of-the art graphing software, and documentation of data and results using electronic laboratory notebooks;
- Coordinate with external contract research organizations for assay development, hit finding activities and routine compound screening;
- Operate and maintain laboratory equipment such as multimodal microplate readers, microplate washers and liquid handlers of varying capacity;
- Develop processes for storage, retrieval and assay-ready plating workflows for Accent chemical matter;
- Perform lab-based research with minimal supervision in a collaborative, fast-paced and dynamic environment;
- Independently summarize, analyze and present your work to project and senior leadership teams
Qualifications and skills:
- B.A./B.S. in Biochemistry, Enzymology or related field plus a minimum of 6 years of industry experience or the equivalent expertise; or Masters or Ph.D. plus a minimum of 4 years of experience;
- Knowledge of enzymology, enzyme kinetics and current assay approaches for several enzymatic classes and protein-protein-interaction screening formats;
- Familiarity with current plate readers, liquid handlers and other tools to execute assay development and routine screening;
- Experience in state-of-the-art data visualization, graphing and curve fitting software;
- Knowledge of research informatics inventory and assay databases;
- Strong attention to detail and the ability to multi-task required;
- Familiarity with high throughput screening using multiple modalities (e.g. enzymatic assays, binding assays) and hit validation desired;
- Experience with fragment screening and validation desired;
- Experience with outsourcing desired
Position: Full-Time, Exempt
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Senior / Principal Research Associate, Biology
Position Summary:
As a key member of the Biology team, this Senior or Principal Research Associate will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of RNA modification in human disease, and progress the Accent pipeline.
Responsibilities:
- Execute cell and molecular biology studies to investigate the role of novel RNA modification pathways in human disease;
- Assist with the development of cell-based assays to be used in support of medicinal chemistry efforts and structure activity relationship assessment;
- Maintain good written records of laboratory procedures, results and conclusions;
- Perform and report interim analysis of accumulated data to project teams and Accent leadership;
- Assist in the development of and compliance with all Accent policies and operational guidelines;
- Participate in various aspects of small company capability building
Qualifications:
- BS/MS in Biology or related field with a minimum of 3+ years relevant industry experience or the equivalent expertise;
- Proficiency with mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
- Excellent organizational and communication skills;
- Ability to design and execute experiments, analyze and document results as part of a fast-paced research team
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
