Position Summary:

As a key member of the Protein and Structural Sciences team, the Senior Scientist will apply her/his strong background in the field of structural biology to provide insights that will advance Accent’s drug discovery programs, work with internal and external teams to execute structure-based efforts and protein production, and collaborate with a cross-functional team of internal and external scientists to progress the Accent pipeline.

Responsibilities:

• Guide experimental structure-based drug design efforts including construct design, protein production, crystallization and structure determination utilizing an outsourcing model;
• Deliver and present high-quality structure data to cross-functional project teams to enable iterative structure-based drug design;
• Analyze proprietary and public structural information to positively impact computational and medicinal chemistry efforts;
• Evaluate structures and develop structure-activity relationships in collaboration with medicinal and computational chemists as a part of the overall hit-to-lead process;
• Guide protein production efforts for biochemical and biophysical assays and structural biology activities through collaboration with internal and external scientists;
• Characterize proteins utilizing experimental techniques, including Bioanalyzer, DSF and enzymatic assays

Qualifications and skills:

• PhD in Structural Biology, Biophysics or Biochemistry with 3+ years industry experience in protein crystallography or Masters with 6+ years industry experience in protein crystallography;

• Deep expertise in protein crystallization and X-ray structure determination of protein-ligand complexes and a track record of utilizing structure-based methods to positively impact drug discovery projects;
• Knowledge of protein structure and function, with the ability to communicate structural information to a broad audience;
• Demonstrated competency in protein construct design as well as expression and purification strategies;
• Proficient in recombinant protein production in E. coli, insect cell and mammalian cell systems;

• Excellent communication, interpersonal and organizational skills are essential;

• Experience with biophysical techniques (DSF, ITC, MST, NMR, and/or SPR) that are complementary to x-ray crystallography;
• Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude, motivated by a desire to create the novel cancer therapeutics and the vision to offer cancer patients novel therapies that extend and improve their lives

 Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

As a key member of the Biology team, this Senior or Principal Research Associate will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of RNA modification in human disease, and progress the Accent pipeline.

Responsibilities:

• Execute cell and molecular biology studies to investigate the role of novel RNA modification pathways in human disease;
• Assist with the development of cell-based assays to be used in support of medicinal chemistry efforts and structure activity relationship assessment;
• Maintain good written records of laboratory procedures, results and conclusions;
• Perform and report interim analysis of accumulated data to project teams and Accent leadership;
• Assist in the development of and compliance with all Accent policies and operational guidelines;
• Participate in various aspects of small company capability building

Qualifications:

• BS/MS in Biology or related field with a minimum of 3+ years relevant industry experience or the equivalent expertise;
• Proficiency with mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
• Excellent organizational and communication skills;
• Ability to design and execute experiments, analyze and document results as part of a fast-paced research team

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.