+-Principal Scientist/Associate Director, Medicinal Chemistry
Position Summary:
As a senior medicinal chemist reporting to the Head of Chemistry, this person will implement the medicinal chemistry strategy while collaborating with a cross-functional team of scientists and lead a team of external synthetic chemistry resources to progress multiple drug discovery programs.
Responsibilities:
- Co-lead interdisciplinary project teams and work with a team of scientists to progress projects from target selection and validation through candidate selection;
- Design and oversee synthesis of novel chemical entities aimed to optimize biochemical and cell potency, selectivity, pharmacokinetic properties and in vivo efficacy;
- Contribute to execution of IP strategy in collaboration with internal and external intellectual property attorneys;
- Oversee activities at partner CROs
Qualifications and skills:
- Ph.D. in synthetic organic chemistry or medicinal chemistry with a minimum of 5 years of medicinal chemistry experience in the pharmaceutical industry;
- Hands-on experience in successfully designing and synthesizing novel small molecule therapies;
- Extensive knowledge in the current practice and literature of synthetic and medicinal chemistry;
- Strong understanding of structure-based design, physicochemical properties, and DMPK;
- Experience with computational software, electronic notebooks and LIMS;
- Experience in co-leading discovery projects;
- Effective oral and written communication with peers and people in other functional areas;
- Ability to work independently and in a dynamic team environment;
- Knowledge and experience of fragment approaches and/or novel protein targets are desirable;
- Experience in screening and hit validation activities for enzymatic and binding assays is desirable;
- Experience in outsourcing and managing CROs is a plus;
- Experience in oncology is a plus
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Associate Director, Finance
Position Summary:
As a key member of the Finance & Operations team reporting to the Chief Financial Officer, this role will have broad accounting, finance and operational finance responsibilities.
Responsibilities:
- Lead the monthly, quarterly and annual accounting close;
- Prepare monthly, quarterly and annual financial reporting packages;
- Lead budgeting and forecasting activities working with team leaders across the company;
- Research and prepare technical accounting memos and analyses, as needed;
- Lead internal control processes and improvements, including implementing system and process upgrades, as needed;
- Support treasury and cash planning activities;
- Oversee accounts payable activities;
- Process semi-monthly payrolls, maintaining strong supporting records; and
- Respond to ad hoc requests for financial support, including organizing and providing supporting documentation in response to independent audit requests and to support tax return preparation
Qualifications and skills:
- Attention to detail and strong organizational skills;
- Ability to work independently;
- Aptitude for process improvement, desire to drive efficiencies and learn the business holistically;
- Bachelor’s degree in Finance or Accounting preferred;
- Minimum five years of experience in a finance function
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Senior / Principal Research Associate, Biology
Position Summary:
As a key member of the Biology team, this Senior or Principal Research Associate will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of RNA modification in human disease, and progress the Accent pipeline.
Responsibilities:
- Execute cell and molecular biology studies to investigate the role of novel RNA modification pathways in human disease;
- Assist with the development of cell-based assays to be used in support of medicinal chemistry efforts and structure activity relationship assessment;
- Maintain good written records of laboratory procedures, results and conclusions;
- Perform and report interim analysis of accumulated data to project teams and Accent leadership;
- Assist in the development of and compliance with all Accent policies and operational guidelines;
- Participate in various aspects of small company capability building
Qualifications:
- BS/MS in Biology or related field with a minimum of 3+ years relevant industry experience or the equivalent expertise;
- Proficiency with mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
- Excellent organizational and communication skills;
- Ability to design and execute experiments, analyze and document results as part of a fast-paced research team
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
