+-Senior / Principal Scientist, Protein and Structural Sciences (Biophysics)
Position Summary:
As a key member of the Protein and Structural Sciences team, the Senior / Principal Scientist will play a critical and influential role in the application of biophysical methods in drug discovery. Reporting to the Director of Protein & Structural Sciences, the Senior / Principal Scientist will apply biophysical methods to understand small molecule-protein interactions and work cross-functionally with teams of internal and external scientists to utilize this expertise to provide insights that will advance Accent’s drug discovery programs.
Responsibilities:
- Design, execute, and analyze key Surface Plasmon Resonance (SPR) experiments for small molecule compound screening with a high level of independence to support hit finding, lead optimization and mechanism of inhibition studies;
- Maintain internal databases with latest results and contribute to optimization of LIMS systems for biophysical data;
- Effectively communicate biophysical information and results to a variety of audiences in multiple settings, including project teams and company management;
- Oversee activities at partner CROs producing biophysical data; and
- Establish and manage an internal SPR facility at Accent
Qualifications and Skills:
- A PhD or BS/MS with equivalent experience in Biophysics, Biochemistry, Bioanalytical Chemistry or a closely related field;
- 4+ years of experience in industry with 2+ years laboratory experience using SPR spectroscopy, experience with Biacore platforms preferred;
- Extensive knowledge and experience with SPR and other biophysical techniques (including DSF, ITC, MST and NMR), with the ability to communicate complex information to a broad audience
- Proficiency in operating and maintaining SPR systems and associated data processing packages;
- Demonstrated commitment to innovation and scientific rigor across multiple protein targets and superfamilies;
- Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude;
- Experience with outsourcing preferred;
- Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude, motivated by a desire to create the novel cancer therapeutics and the vision to offer cancer patients novel therapies that extend and improve their lives
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Scientist / Senior Scientist, Bioinformatics
Position Summary:
As a key member of the Biology team, the Scientist/Senior Scientist, Bioinformatics will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of RNA modification in human disease and progress the Accent pipeline.
Responsibilities:
- Application of ‘omics data analyses (including, but not limited to, RNA-seq, RIP-seq and proteomics) to extract biological insights such as compound mechanism of action, therapeutic strategy and disease biology relating to RNA modifications;
- Identify, internalize, and analyze data from public resources (e.g. TCGA, CCLE, cBioportal, Depmap) and the scientific literature;
- Creation of clear and engaging data visualizations and interactive tools; and
- Work effectively in a cross-functional capacity within internal project teams to determine experimental approach and deliver high-quality results
Qualifications and Skills:
- Ph.D. in bioinformatics, computational biology, biostatistics or a related field; or M.S. with 3+ years of experience;
- Strong scientific understanding of molecular biology and genomics;
- Experience with NGS and other ‘omic data analyses, including some of the following: RNA-seq, RIP-seq, proteomics, copy number and mutation quantification, and single cell sequencing;
- Deep knowledge of public genomic, transcriptomic databases and tools (e.g. TCGA, CCLE, cBioportal, Depmap, IGV, ESEMBL);
- Extensive experience with at least one programming and scripting language (e.g. Python, R);
- Demonstrated self-starter mentality that keeps current with emerging trends in bioinformatics and computational biology;
- Excellent organizational and communication skills;
- Ability to work in a dynamic and fast-paced environment independently and efficiently;
- Experience with RNA biology or oncology a plus
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Senior Accountant / Accounting Manager
Position Summary:
As a key member of the Finance & Operations team reporting to the Director of Finance, the Senior Accountant / Accounting Manager will have broad accounting, finance, and operational responsibilities. The Senior Accountant / Accounting Manager will actively collaborate cross-functionally across the organization, gain foundational experience and contribute to the growth and evolution of the Finance department and organization.
Responsibilities:
- Manage day-to-day transactional accounting activities, including preparing and posting journal entries, accounts payable processing and payments;
- Process semi-monthly payrolls, maintaining strong supporting records and preparing payroll-related reconciliations;
- Prepare month-end, quarter-end, and annual closing packages including financial statements and assist with accelerating the accounting close process;
- Support budgeting and forecasting activities including collaboration with R&D, Operations, and others across the organization;
- Partner with Director of Finance in developing policies and interpretation of US GAAP guidance for key accounting and reporting areas, including internal controls and research and analysis of technical accounting matters as needed;
- Support implementation and adoption of new accounting, reporting, and procurement systems (e.g., Netsuite, Coupa); and
- Respond to ad hoc requests for financial support, including organizing and providing supporting documentation in response to independent audit requests and to support tax return preparation
Qualifications and Skills:
- Bachelor’s degree in Finance, Accounting, or related field;
- Knowledge of US GAAP and relevant accounting and financial concepts;
- A minimum of 2 years of experience in roles of increasing responsibility – public accounting and/or life sciences/biotech industry experience preferred;
- Active CPA license or pursuing CPA license preferred;
- Experience with an accounting ERP (e.g., Quickbooks, Netsuite, etc.) a plus;
- Attention to detail and strong organizational skills;
- Motivated, self-starter mentality and ability to work independently;
- Aptitude for process improvement, desire to drive efficiencies and learn the business holistically;
- Excellent communication skills and ability to effectively collaborate with others in a team environment;
- Comfortable working in a fast-paced, evolving, start-up environment;
- Proficiency in MS Office, particularly Excel
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
