Position Summary:

As a key member of the Protein and Structural Sciences team, the Senior Scientist will apply her/his strong background in the field of structural biology to provide insights that will advance Accent’s drug discovery programs, work with internal and external teams to execute structure-based efforts and protein production, and collaborate with a cross-functional team of internal and external scientists to progress the Accent pipeline.

Responsibilities:

• Guide experimental structure-based drug design efforts including construct design, protein production, crystallization and structure determination utilizing an outsourcing model;
• Deliver and present high-quality structure data to cross-functional project teams to enable iterative structure-based drug design;
• Analyze proprietary and public structural information to positively impact computational and medicinal chemistry efforts;
• Evaluate structures and develop structure-activity relationships in collaboration with medicinal and computational chemists as a part of the overall hit-to-lead process;
• Guide protein production efforts for biochemical and biophysical assays and structural biology activities through collaboration with internal and external scientists;
• Characterize proteins utilizing experimental techniques, including Bioanalyzer, DSF and enzymatic assays

Qualifications and skills:

• PhD in Structural Biology, Biophysics or Biochemistry with 3+ years industry experience in protein crystallography or Masters with 6+ years industry experience in protein crystallography;

• Deep expertise in protein crystallization and X-ray structure determination of protein-ligand complexes and a track record of utilizing structure-based methods to positively impact drug discovery projects;
• Knowledge of protein structure and function, with the ability to communicate structural information to a broad audience;
• Demonstrated competency in protein construct design as well as expression and purification strategies;
• Proficient in recombinant protein production in E. coli, insect cell and mammalian cell systems;

• Excellent communication, interpersonal and organizational skills are essential;

• Experience with biophysical techniques (DSF, ITC, MST, NMR, and/or SPR) that are complementary to x-ray crystallography;
• Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude, motivated by a desire to create the novel cancer therapeutics and the vision to offer cancer patients novel therapies that extend and improve their lives

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

As a member of the Lead Discovery team, reporting to the Head of Lead Discovery, the Principal Scientist or Associate Director will oversee the development and implementation of biochemical assays for internal and external use and collaborate with a cross-functional team of scientists to support drug discovery efforts across the Accent portfolio.

Responsibilities:

• Direct the design and execution of biochemical assays for multiple novel target classes for use in identification and characterization of small molecule inhibitors with internal and external resources;
• Oversee external contract research organizations performing varied activities on program targets, including assay development, assay transfer, compound screening and hit validation, enabling effective communication between companies and ensuring proper documentation of results while maintaining aggressive project timelines;
• Maintain broad knowledge of biochemical mechanisms of program targets and as well as stay current in advances in biochemistry and enzymology methodologies, techniques and technologies;
• Apply knowledge, expertise, and leadership skills to cross-functional project and other matrix-organized teams;
• Effectively communicate discipline and project plans and results to diverse audiences, (i.e., project teams, senior leadership, external partners)

Qualifications and skills:

• A./B.S./MS/PhD in Biochemistry, Enzymology or related field plus a minimum of 8 years of industry experience;
• Expertise in the areas of enzymology, enzyme kinetics and current assay approaches for several enzymatic classes and protein-protein-interaction screening formats; knowledge of high throughput screening methods and hit validation techniques;
• Success with utilization of in-house and external resources to advance programs from assay development to lead optimization;
• General knowledge of other early drug discovery functional areas, including biological target validation, biophysical methods, structural biology techniques and medicinal chemistry;
• Demonstrated leadership in cross-functional teams;
• Effective communication skills;
• Strong attention to detail and the ability to work on multiple programs in parallel;
• Record of scientific accomplishments at conferences or in peer-reviewed journals and/or patents a plus

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

Reporting to the VP of Chemistry, the Director of Drug Metabolism and Pharmacokinetics (DMPK) will bring extensive experience in ADME and DMPK to strengthen the discovery and development program teams at Accent. She or he will be responsible for comprehensive DMPK support, including design, execution and interpretation of all DMPK studies, PK/PD modelling, collaboration with colleagues on non-clinical toxicology and translational studies of all discovery and development programs.  As a core member of the program teams, she or he will devise, drive and implement strategies and analyses which will support all aspects of the optimization and promote progression of our oncology-focused small molecule therapies.

Responsibilities

• Serve as the DMPK lead within the research department;
• Identify critical ADME/DMPK needs and strategies;
• Act as a DMPK representative to ensure effective application and integration of ADME, PK and PK/PD studies in support of discovery and development programs;
• Work with development teams to support human ADME, human PK, dose projections and DDI studies;
• Deliver and communicate results to project teams to enable decision making;
• Manage interactions with external CROs to ensure high quality and on-time execution of DMPK studies;
• Maintain complete and timely data archiving;
• Write and review relevant sections of regulatory documents

Requirements

• PhD., Pharm. D. or equivalent training in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, or related disciplines, with 10 years of relevant experience in the bio/pharmaceutical industry or relevant CROs;
• In-depth understanding and strategic application of in vitro and in vivo ADME assays, methods and models;
• Direct hands-on experience and troubleshooting skills in in vitro and in vivo DMPK studies, including PK and PK/PD analyses, quantitative and qualitative LC-MS analysis, in vitro and in vivo biotransformation and human PK and drug interaction predictions is a plus;
• Expertise in managing CROs and sound knowledge of regulatory guidelines on bioanalysis, GLP practice and DDIs;
• Proficiency in Phoenix WinNonlin (classic WNL and PHX Model), or similar systems;
• Ability to develop user-specified mathematical models highly desired;
• Strong analytical, organizational and communication skills, and a consummate team player

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary

The Director of Alliance Management will be instrumental in the strategic planning and execution of key Accent partnerships, including its foundational multi-program partnership with AstraZeneca. This highly visible, highly collaborative role will work broadly across the organization and cross-functionally with internal and external stakeholders.  Reporting to the Vice President, Head of Business Development, the Director of Alliance Management will be responsible for all aspects of Alliance Management and for effectively communicating plans and partnership objectives to key stakeholders and executive management.

Responsibilities

• Perform all aspects of Alliance Management, including scheduling, developing agendas, drafting minutes, actions, and follow-up; as well as manage, as needed, Joint Steering Committee and Joint Project Team activities, with oversight over partnership activity timelines, budgets, etc.;
• Develop and maintain exceptional business and scientific relationships with key internal and external stakeholders, working to gain consensus across organizations and striving to meet partnership goals and objectives;
• Leverage input from all critical organizational functions to create integrated plans for the alliance that define goals, milestones, decision points, critical paths, financial assumptions and tracking, timelines, and alternative scenarios;
• Serve as a key point person for program team members on project-related communication, proactive issue identification and risk-mitigation;
• Drive process, with legal representatives, to amend contracts or execute supplementary agreements as needed within collaborations;
• Conduct periodic partnership performance assessments with key stakeholders and implement solutions or improvements to optimize alliance performance and to maintain strong working relationships;
• Serve as an ambassador for Alliance Management within the company;
• Opportunity to provide support to key Business Development and/or New Product Planning/Portfolio Strategy-related activities

Requirements

• BS/BA in life sciences or related area (MBA/PhD preferred) with eight or more years of biotech and/or pharmaceutical industry experience;
• Significant understanding of the pharmaceutical research and development process and the regulatory process by which drug products are filed and approved;
• Comfort interpreting and managing deliverables under collaboration contracts;
• Excellent project management skills, including ability to manage collaborations across multiple programs and anticipate and resolve issues;
• Demonstrated ability to coordinate cross-functional teams and meet deadlines;
• Strong interpersonal and communication skills, including ability to clearly articulate complex issues;
• Excellent time management and organizational skills, demonstrating an ability to work independently, meet deadlines and prioritize work effectively;
• Ability to work effectively and congenially in a team setting with a collaborative mindset, consensus-building disposition, and culture-focus;
• Strong problem-solving, analytical skills, and excellent business judgment;
• Demonstrated self-starter mentality with a flexible approach to learning and taking on new challenges;
• Comfortable working in fast-paced, evolving, high-growth environment;
• Strong character, sense of humor, work ethic, detail-orientation, and results-driven outlook

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

As a key member of the Biology team, this Senior or Principal Research Associate will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of RNA modification in human disease, and progress the Accent pipeline.

Responsibilities:

• Execute cell and molecular biology studies to investigate the role of novel RNA modification pathways in human disease;
• Assist with the development of cell-based assays to be used in support of medicinal chemistry efforts and structure activity relationship assessment;
• Maintain good written records of laboratory procedures, results and conclusions;
• Perform and report interim analysis of accumulated data to project teams and Accent leadership;
• Assist in the development of and compliance with all Accent policies and operational guidelines;
• Participate in various aspects of small company capability building

Qualifications:

• BS/MS in Biology or related field with a minimum of 3+ years relevant industry experience or the equivalent expertise;
• Proficiency with mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
• Excellent organizational and communication skills;
• Ability to design and execute experiments, analyze and document results as part of a fast-paced research team

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.