Position Summary:

As a senior medicinal chemist reporting to the Head of Chemistry, this person will implement the medicinal chemistry strategy while collaborating with a cross-functional team of scientists and lead a team of external synthetic chemistry resources to progress multiple drug discovery programs.

Responsibilities:

• Co-lead interdisciplinary project teams and work with a team of scientists to progress projects from target selection and validation through candidate selection;
• Design and oversee synthesis of novel chemical entities aimed to optimize biochemical and cell potency, selectivity, pharmacokinetic properties and in vivo efficacy;
• Contribute to execution of IP strategy in collaboration with internal and external intellectual property attorneys;
• Oversee activities at partner CROs

Qualifications and skills:

• Ph.D. in synthetic organic chemistry or medicinal chemistry with a minimum of 7 years of medicinal chemistry experience in the pharmaceutical industry;
• Hands-on experience in successfully designing and synthesizing novel small molecule therapies;
• Extensive knowledge in the current practice and literature of synthetic and medicinal chemistry;
• Strong understanding of structure-based design, physicochemical properties, and DMPK;
• Experience with computational software, electronic notebooks and LIMS;
• Experience in co-leading discovery projects;
• Effective oral and written communication with peers and people in other functional areas;
• Ability to work independently and in a dynamic team environment;
• Knowledge and experience of fragment approaches and/or novel protein targets are desirable;
• Experience in screening and hit validation activities for enzymatic and binding assays is desirable;
• Experience in outsourcing and managing CROs is a plus;
• Experience in oncology is a plus

 Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

As a member of the Lead Discovery team, reporting to the Head of Lead Discovery, the Senior or Principal Scientist will develop and implement biochemical assays for internal and external use and collaborate with a cross-functional team of scientists to support drug discovery efforts across the Accent portfolio.

Responsibilities:

• Design and execution of biochemical assays for multiple novel target classes for use in screening and characterizing small molecule inhibitors;
• Analyze data, including curve fitting and IC50 calculations using state-of-the art graphing software, and documentation of data and results using electronic laboratory notebooks;
• Coordinate with external contract research organizations for assay development, hit finding activities and routine compound screening;
• Operate and maintain laboratory equipment such as multimodal microplate readers, microplate washers and liquid handlers of varying capacity;
• Develop processes for storage, retrieval and assay-ready plating workflows for Accent chemical matter;
• Perform lab-based research with minimal supervision in a collaborative, fast-paced and dynamic environment;
• Independently summarize, analyze and present your work to project and senior leadership teams

Qualifications and skills:

• B.A./B.S. in Biochemistry, Enzymology or related field plus a minimum of 6 years of industry experience or the equivalent expertise; or Masters or Ph.D. plus a minimum of 4 years of experience;
• Knowledge of enzymology, enzyme kinetics and current assay approaches for several enzymatic classes and protein-protein-interaction screening formats;
• Familiarity with current plate readers, liquid handlers and other tools to execute assay development and routine screening;
• Experience in state-of-the-art data visualization, graphing and curve fitting software;
• Knowledge of research informatics inventory and assay databases;
• Strong attention to detail and the ability to multi-task required;
• Familiarity with high throughput screening using multiple modalities (e.g. enzymatic assays, binding assays) and hit validation desired;
• Experience with fragment screening and validation desired;
• Experience with outsourcing desired

Position:  Full-Time, Exempt

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.