+-Manager / Senior Manager, Informatics
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Operations team reporting to the Senior Manager of Research Operations, the Informatics Manager will manage, support, and develop our research informatics and data management platforms. The Informatics Manager will actively collaborate cross-functionally to lead the development and evolution of the informatics platform to support Accent’s continued growth.
Responsibilities:
- Oversee informatics infrastructure by managing, upgrading, and coordinating service across all of Accent’s SaaS (Software as a Service) platforms;
- Design, implement and document system configurations for new and existing informatics system implementation, including sample management, results analysis, lab workflow, release & stability management, electronic lab notebooks (ELN) etc.;
- Collaborate with key internal and external stakeholders, including internal scientists in the DMPK, Biology, Molecular Discovery, and Chemistry teams to support and enhance informatics platforms;
- Coordinate software needs of internal groups with SaaS providers and work with SaaS providers in future product design and improvement (e.g., automation of processes such as data capture and registration);
- Negotiate and coordinate the renewal of SaaS provider and consultant contracts annually;
- Support weekly registration activities of compounds and biologics;
- Conduct system testing prior to new feature releases; coordinate new user training and host quarterly informatics user group sessions;
- Assist users with creating new protocols, assays, dashboards, queries, etc. in the ELN and other data analysis/visualization platforms;
- Assist with system support, maintenance, and administration of lab equipment, such as:
- Robotic liquid handlers from TECAN and Agilent Technologies
- Readers from PerkinElmer, BMG Labtech, etc.
Qualifications:
- M.S. with at least 3+ years of industry experience in research informatics, data management, data engineering; or Bachelor’s degree with 4+ years of experience;
- Experience in implementing a major, commercial SaaS LIMS product preferred;
- Working knowledge of biology, biophysics, chemistry, and preclinical data;
- Working knowledge of Windows and Linux operating systems;
- Experience with REST API and Amazon Web Services (AWS) Research compute environment is preferred;
- Excellent organizational skills and ability to multi-task in an extremely fast-paced environment;
- Working knowledge of AGILE principles is a plus;
- Strong communication, interpersonal and collaboration skills in order to successfully partner with internal and external stakeholders;
- Solid analytical and problem-solving abilities
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Associate Director / Director, Protein and Structural Sciences
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
The Head of Protein and Structural Sciences is responsible for leading an internal team to support structure-based efforts, biophysical experiments, and protein production for the diverse targets within the company pipeline. The successful candidate will use internal resources and CRO capabilities as well as collaborate with cross-functional teams to progress Accent programs. This position reports to the Vice President of Molecular Discovery.
Responsibilities:
- Manage an internal team of biophysicists and structural biologists to find creative solutions to challenges that enable program progression from target validation through development candidate selection
- Lead all aspects of experimental structure-based drug design efforts including construct design, protein production, crystallization, and structure determination utilizing an experimental outsourcing model and internal team members
- Analysis of proprietary and public structural information to positively impact computational and medicinal chemistry efforts
- Manage protein production efforts for biochemical assays, biophysical methods, high throughput screening, and structural biology activities through collaboration with internal and external scientists
- Effectively communicate complex information to internal and external audiences
- Establish relationships, manage contracts, and oversee activities at partner CROs
Qualifications and skills:
- PhD in Structural Biology, Biophysics, Biochemistry, or a closely related field plus at least 10 years of industry experience or the equivalent expertise
- Experience in managing and mentoring multiple direct reports
- Deep expertise in protein crystallization and X-ray structure determination of protein-ligand complexes and a track record of utilizing structure-based methods to positively impact drug discovery projects; success with fragment-based drug discovery highly desirable
- Extensive knowledge of protein structure and function, with the ability to communicate complex information to a broad audience
- Demonstrated competency in protein construct design as well as expression and purification strategies
- Experience with other structural and biophysical techniques (e.g. computational modeling, EM, SAXS, NMR, SPR, ITC) is preferred
- Experience with outsourcing desired
- A track record of innovation and scientific rigor
- Demonstrated leadership on project teams (Project or Department/Discipline lead) and/or in matrixed organizations is desired
- Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude, motivated by a desire to offer cancer patients novel therapies that extend and improve their lives
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Director, Intellectual Property
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017 and named as one of Fortune’s 50 Top Ten Workplaces in Healthcare and Biopharma and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
Reporting to the Chief Financial Officer, the Director of Intellectual Property will play a key strategic role in architecting and managing the Company’s intellectual property strategy and portfolio. This key role will direct and oversee all intellectual property matters, working with outside counsel and internal team members to strategically evaluate intellectual property opportunities; prepare, review, file, and prosecute patent applications; and monitor patent, regulatory and competitive landscapes. The ideal candidate will be a trusted advisor and business partner with the ability to identify and align strategic opportunities to critical business objectives.
Responsibilities:
- Develop and execute creative and thoughtful strategies to protect the company’s intellectual property;
- Work closely with R&D teams to build strong patent portfolios around key assets to ensure long-term competitive advantage by identifying and evaluating new inventions, conducting prior art searches, managing new and existing patent portfolios, and responding to administrative challenges instituted by third parties;
- Identify, monitor and analyze competitive intellectual property and potential freedom-to-operate matters;
- Manage outside counsel on worldwide patent prosecution and maintenance and work with outside counsel to draft and prosecute the company’s patent applications;
- Review proposed publications and presentations for potential disclosure issues;
- Provide advice and cross-functional support for R&D, business development, alliance management, project teams and other functional areas through all phases of research and development;
- Working with management, prepare, negotiate, and review contracts and agreements;
- Support IP due diligence and agreement review/negotiation related to partnering activities;
- Educate and advise colleagues on IP processes and best practices;
- Work with the executive leadership team to implement and administer IP policies and best practices
Qualifications and skills:
- 5+ years of experience practicing intellectual property law, with an emphasis on small molecule patent prosecution, at a large law firm and/or in-house legal department;
- Registered to practice before the U.S. Patent and Trademark Office;
- J.D. from an accredited law school;
- Thorough understanding of U.S. patent law and familiar with foreign patent laws in major countries;
- Excellent interpersonal, communication and presentation skills, including ability to communicate complex issues clearly and succinctly;
- Ability to think strategically with a broad perspective;
- Strong organizational skills, including careful attention to detail and ability to manage and prioritize multiple matters simultaneously and to respond to rapidly shifting priorities in ambiguous or challenging situations;
- Ability to work collaboratively as a business partner and to recognize and respond quickly, clearly and pragmatically to urgent situations and opportunities;
- Ph.D. or other advanced degree in organic chemistry or chemical sciences preferred
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Research Associate / Senior Research Associate, Biology
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017 and named as one of Fortune’s 50 Best Small Workplaces in 2019 and a Fierce15 biotech company in 2020, Accent is building a highly collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Biology team, this Research Associate or Senior Research Associate will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of epitranscriptomics in human disease, and progress the Accent pipeline.
Responsibilities:
- Execute cell and molecular biology studies to investigate the role of novel epitranscriptomic pathways in human disease;
- Assist with the development of cell-based assays to be used in support of medicinal chemistry efforts and structure activity relationship assessment;
- Maintain good written records of laboratory procedures, results and conclusions.
Qualifications:
- BS/MS in Biology or related field with 1-2 years of relevant industry experience or the equivalent expertise;
- Proficiency with mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
- Knowledge of laboratory automation a plus;
- Excellent organizational and communication skills;
- Ability to design and execute experiments, analyze and document results as part of a fast-paced research team.
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Senior Research Associate / Principal Research Associate, Biology
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017 and named as one of Fortune’s 50 Best Small Workplaces in 2019 and a Fierce15 biotech company in 2020, Accent is building a highly collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Biology team, this Senior or Principal Research Associate will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of epitranscriptomics in human disease, and progress the Accent pipeline.
Responsibilities:
- Execute cell and molecular biology studies to investigate the role of novel epitranscriptomic pathways in human disease;
- Assist with the development of cell-based assays to be used in support of medicinal chemistry efforts and structure activity relationship assessment;
- Maintain good written records of laboratory procedures, results and conclusions;
- Perform and report interim analysis of accumulated data to project teams and Accent leadership;
- Assist in the development of and compliance with all Accent policies and operational guidelines;
- Participate in various aspects of small company capability building.
Qualifications:
- BS/MS in Biology or related field with a minimum of 3+ years relevant industry experience or the equivalent expertise;
- Proficiency with mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
- Ability to design and execute experiments, analyze and document results as part of a fast-paced research team;
- Knowledge of laboratory automation a plus;
- Excellent organizational and communication skills
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Senior Scientist, Medicinal Chemistry
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017 and named as one of Fortune’s 50 Best Small Workplaces in 2019, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Medicinal Chemistry team, the Senior Scientist will help oversee the advancement of Accent’s drug discovery pipeline. This role will collaborate cross-functionally with our internal and external teams to analyze data, understand structure-activity relationships, design chemical matter and work with our external synthetic chemistry partners to deliver these compounds to progress multiple drug discovery programs.
Responsibilities:
- Lead and direct the design and synthesis of chemical matter for a key program utilizing an outsourcing model
- Develop and implement synthetic sequences to access chemical matter and troubleshoot synthetic issues as they arise
- Interpret data from various sources and carry out integrated structure-activity relationship analysis to support the design of new chemical matter to optimize biochemical and cell potency, selectivity, pharmacokinetic properties, and in vivo efficacy
- Deliver and present high-quality data to diverse audiences (e.g., cross-functional project teams, external partners)
Qualifications and skills:
- PhD in Organic Chemistry or related field with some industry experience or BS/MS with 4+ years of industry experience
- Familiarity with small molecule drug discovery approaches
- Ability to interpret data from diverse sources and design chemical matter that addresses liabilities and shortcomings
- A track record of problem solving
- Deep understanding of synthetic organic chemistry
- Effective communicator in program team settings
- Experience with multiple target classes is a plus
- Prior experience in chemistry CRO management is a plus
- Experience in oncology is a plus
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Scientist / Senior Scientist, Bioinformatics
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As the Scientist/Senior Scientist of Bioinformatics, you will be joining a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of RNA modification in human disease and progress the Accent pipeline.
Responsibilities:
- Application of ‘omics data analyses (including, but not limited to, RNA-seq, RIP-seq and proteomics) to extract biological insights such as compound mechanism of action, therapeutic strategy, and disease biology
- Identify, internalize, and analyze data from public resources (e.g. TCGA, CCLE, cBioportal, DepMap) and the scientific literature
- Work with interdisciplinary teams to support identifying and prioritizing targets
- Work with biology and translational medicine team to support identifying and validating biomarkers and target patient’s profiles through analyzing internal and public cell line screening data
- Identify, evaluate, and internalize public algorithms/tools and create analysis workflows for routine internal data analysis
- Create clear and engaging data visualizations and interactive tools
- Work effectively in a cross-functional capacity within internal project teams to determine the experimental approaches and deliver high-quality results
Qualifications and skills:
- MS or Ph.D. in bioinformatics, computational biology, biostatistics, or a related field
- Track record of publications in relevant field is a plus
- 2+ years post graduate or industry experience
- Strong scientific understanding of molecular biology and genomics
- Deep knowledge and experience of mining public -omics resources (e.g. TCGA, CCLE, cBioportal, DepMap, Ensembl) to support target/biomarker discovery
- Demonstrating data mining and machine learning skills
- Experience of patient stratification biomarker analysis in pre-clinical and clinical settings is a plus
- Experience with NGS and other ‘omic data analyses, including some of the following: RNA-seq, RIP-seq, proteomics, copy number and mutation quantification, and single-cell sequencing
- Familiarity with bioinformatics tools, statistical methods and pipelines, experience with workflow management tools (e.g, Snakemake)
- Ability to implement and test published algorithms/tools
- Extensive experience with at least one programming and scripting language (e.g. Python, R)
- Comfortable working in Linux/Unix system
- Experience with cloud computing is a plus
- Experience with best-practice software development (e.g., version control) is a plus
- Demonstrated self-starter mentality that keeps current with emerging trends in bioinformatics and computational biology
- Excellent organizational and communication skills
- Ability to work in a dynamic and fast-paced environment independently and efficiently
- Experience with RNA biology or oncology is a plus
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
