Position Summary:

As a key member of the Protein and Structural Sciences team, the Senior Scientist will apply her/his strong background in the field of structural biology to provide insights that will advance Accent’s drug discovery programs, work with internal and external teams to execute structure-based efforts and protein production, and collaborate with a cross-functional team of internal and external scientists to progress the Accent pipeline.

Responsibilities:

• Guide experimental structure-based drug design efforts including construct design, protein production, crystallization and structure determination utilizing an outsourcing model;
• Deliver and present high-quality structure data to cross-functional project teams to enable iterative structure-based drug design;
• Analyze proprietary and public structural information to positively impact computational and medicinal chemistry efforts;
• Evaluate structures and develop structure-activity relationships in collaboration with medicinal and computational chemists as a part of the overall hit-to-lead process;
• Guide protein production efforts for biochemical and biophysical assays and structural biology activities through collaboration with internal and external scientists;
• Characterize proteins utilizing experimental techniques, including Bioanalyzer, DSF and enzymatic assays

Qualifications and skills:

• PhD in Structural Biology, Biophysics or Biochemistry with 3+ years industry experience in protein crystallography or Masters with 6+ years industry experience in protein crystallography;

• Deep expertise in protein crystallization and X-ray structure determination of protein-ligand complexes and a track record of utilizing structure-based methods to positively impact drug discovery projects;
• Knowledge of protein structure and function, with the ability to communicate structural information to a broad audience;
• Demonstrated competency in protein construct design as well as expression and purification strategies;
• Proficient in recombinant protein production in E. coli, insect cell and mammalian cell systems;

• Excellent communication, interpersonal and organizational skills are essential;

• Experience with biophysical techniques (DSF, ITC, MST, NMR, and/or SPR) that are complementary to x-ray crystallography;
• Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude, motivated by a desire to create the novel cancer therapeutics and the vision to offer cancer patients novel therapies that extend and improve their lives

Position:  Full-Time, Exempt

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

As a member of the Lead Discovery team, reporting to the Head of Lead Discovery, the Principal Scientist or Associate Director will oversee the development and implementation of biochemical assays for internal and external use and collaborate with a cross-functional team of scientists to support drug discovery efforts across the Accent portfolio.

Responsibilities:

• Direct the design and execution of biochemical assays for multiple novel target classes for use in identification and characterization of small molecule inhibitors with internal and external resources;
• Oversee external contract research organizations performing varied activities on program targets, including assay development, assay transfer, compound screening and hit validation, enabling effective communication between companies and ensuring proper documentation of results while maintaining aggressive project timelines;
• Maintain broad knowledge of biochemical mechanisms of program targets and as well as stay current in advances in biochemistry and enzymology methodologies, techniques and technologies;
• Apply knowledge, expertise, and leadership skills to cross-functional project and other matrix-organized teams;
• Effectively communicate discipline and project plans and results to diverse audiences, (i.e., project teams, senior leadership, external partners)

Qualifications and skills:

• A./B.S./MS/PhD in Biochemistry, Enzymology or related field plus a minimum of 8 years of industry experience;
• Expertise in the areas of enzymology, enzyme kinetics and current assay approaches for several enzymatic classes and protein-protein-interaction screening formats; knowledge of high throughput screening methods and hit validation techniques;
• Success with utilization of in-house and external resources to advance programs from assay development to lead optimization;
• General knowledge of other early drug discovery functional areas, including biological target validation, biophysical methods, structural biology techniques and medicinal chemistry;
• Demonstrated leadership in cross-functional teams;
• Effective communication skills;
• Strong attention to detail and the ability to work on multiple programs in parallel;
• Record of scientific accomplishments at conferences or in peer-reviewed journals and/or patents a plus

Position:  Full-Time, Exempt

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

Reporting to the VP of Chemistry, the Director of Drug Metabolism and Pharmacokinetics (DMPK) will bring extensive experience in ADME and DMPK to strengthen the discovery and development program teams at Accent. She or he will be responsible for comprehensive DMPK support, including design, execution and interpretation of all DMPK studies, PK/PD modelling, collaboration with colleagues on non-clinical toxicology and translational studies of all discovery and development programs.  As a core member of the program teams, she or he will devise, drive and implement strategies and analyses which will support all aspects of the optimization and promote progression of our oncology-focused small molecule therapies.

Responsibilities

• Serve as the DMPK lead within the research department;
• Identify critical ADME/DMPK needs and strategies;
• Act as a DMPK representative to ensure effective application and integration of ADME, PK and PK/PD studies in support of discovery and development programs;
• Work with development teams to support human ADME, human PK, dose projections and DDI studies;
• Deliver and communicate results to project teams to enable decision making;
• Manage interactions with external CROs to ensure high quality and on-time execution of DMPK studies;
• Maintain complete and timely data archiving;
• Write and review relevant sections of regulatory documents

Requirements

• PhD., Pharm. D. or equivalent training in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, or related disciplines, with 10 years of relevant experience in the bio/pharmaceutical industry or relevant CROs;
• In-depth understanding and strategic application of in vitro and in vivo ADME assays, methods and models;
• Direct hands-on experience and troubleshooting skills in in vitro and in vivo DMPK studies, including PK and PK/PD analyses, quantitative and qualitative LC-MS analysis, in vitro and in vivo biotransformation and human PK and drug interaction predictions is a plus;
• Expertise in managing CROs and sound knowledge of regulatory guidelines on bioanalysis, GLP practice and DDIs;
• Proficiency in Phoenix WinNonlin (classic WNL and PHX Model), or similar systems;
• Ability to develop user-specified mathematical models highly desired;
• Strong analytical, organizational and communication skills, and a consummate team player

Position:  Full-Time, Exempt

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

The Office & Administrative Assistant is a key member of the Operations team reporting to the Executive Assistant and Office Manager. This position will play an integral role in day-to-day operations of the company. This position will help maintain organized and efficient day-to-day operations of  the office as well as provide administrative support to certain members of senior management team. The ideal candidate for this highly visible position is well organized, flexible, professional, and enjoys interacting with people and working in a collaborative, fast-paced environment.

Responsibilities:

• Manage office and kitchen supply inventory, ordering and stocking as needed;
• Coordinate weekly lunch orders;
• Maintain organization and cleanliness of reception area, conference rooms, kitchens, and common areas;
• Coordinate visitors with building security and greet and direct upon arrival;
• Assist in scheduling department and team meetings and manage conference room calendars;
• Provide administrative support to certain members of the senior management team, including calendar management, expense reporting, and travel coordination;
• Coordinate candidate interview schedules;
• Organize new hire office setups and various onboarding needs;
• Manage phone lists;
• Ad-hoc projects as requested.

Qualifications and skills:

• Attention to detail and strong organizational skills;
• Excellent written and verbal communication skills;
• Proactive with the ability to multitask and prioritize;
• Eager to contribute to a team, with the ability to work independently;

• Exceptional interpersonal skills; poise, professionalism and the ability to build relationships;
• Experience working in an administrative role in an office setting preferred;

• Experience with Microsoft Word, Excel, PowerPoint, and Outlook preferred

Position:  Full-Time, Exempt

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

As a key member of the Biology team, this Senior or Principal Research Associate will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of RNA modification in human disease, and progress the Accent pipeline.

Responsibilities:

• Execute cell and molecular biology studies to investigate the role of novel RNA modification pathways in human disease;
• Assist with the development of cell-based assays to be used in support of medicinal chemistry efforts and structure activity relationship assessment;
• Maintain good written records of laboratory procedures, results and conclusions;
• Perform and report interim analysis of accumulated data to project teams and Accent leadership;
• Assist in the development of and compliance with all Accent policies and operational guidelines;
• Participate in various aspects of small company capability building

Qualifications:

• BS/MS in Biology or related field with a minimum of 3+ years relevant industry experience or the equivalent expertise;
• Proficiency with mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
• Excellent organizational and communication skills;
• Ability to design and execute experiments, analyze and document results as part of a fast-paced research team

Position:  Full-Time, Exempt

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.