Position Summary:

As a key member of the Protein and Structural Sciences team, the Senior / Principal Scientist will apply her/his strong background in the field of structural biology to provide insights that will advance Accent’s drug discovery programs, work with internal and external teams to execute structure-based efforts and protein production, and collaborate with a cross-functional team of internal and external scientists to progress the Accent pipeline.

Responsibilities:

• Guide experimental structure-based drug design efforts including construct design, protein production, crystallization and structure determination utilizing an outsourcing model;
• Deliver and present high-quality structure data to cross-functional project teams to enable iterative structure-based drug design;
• Analyze proprietary and public structural information to positively impact computational and medicinal chemistry efforts;
• Evaluate structures and develop structure-activity relationships in collaboration with medicinal and computational chemists as a part of the overall hit-to-lead process;
• Guide protein production efforts for biochemical and biophysical assays and structural biology activities through collaboration with internal and external scientists;
• Characterize proteins utilizing experimental techniques, including Bioanalyzer, DSF and enzymatic assays

Qualifications and skills:

• PhD in Structural Biology, Biophysics or Biochemistry with 3+ years industry experience in protein crystallography or Masters with 6+ years industry experience in protein crystallography;
• Deep expertise in protein crystallization and X-ray structure determination of protein-ligand complexes and a track record of utilizing structure-based methods to positively impact drug discovery projects;
• Knowledge of protein structure and function, with the ability to communicate structural information to a broad audience;
• Demonstrated competency in protein construct design as well as expression and purification strategies;
• Proficient in recombinant protein production in E. coli, insect cell and mammalian cell systems;
• Excellent communication, interpersonal and organizational skills are essential;
• Experience with biophysical techniques (DSF, ITC, MST, NMR, and/or SPR) that are complementary to x-ray crystallography;
• Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude, motivated by a desire to create the novel cancer therapeutics and the vision to offer cancer patients novel therapies that extend and improve their lives

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

Reporting to the VP of Chemistry, the Director of Drug Metabolism and Pharmacokinetics (DMPK) will bring extensive experience in ADME and DMPK to strengthen the discovery and development program teams at Accent. She or he will be responsible for comprehensive DMPK support, including design, execution and interpretation of all DMPK studies, PK/PD modelling, collaboration with colleagues on non-clinical toxicology and translational studies of all discovery and development programs.  As a core member of the program teams, she or he will devise, drive and implement strategies and analyses which will support all aspects of the optimization and promote progression of our oncology-focused small molecule therapies.

Responsibilities

• Serve as the DMPK lead within the research department;
• Identify critical ADME/DMPK needs and strategies;
• Act as a DMPK representative to ensure effective application and integration of ADME, PK and PK/PD studies in support of discovery and development programs;
• Work with development teams to support human ADME, human PK, dose projections and DDI studies;
• Deliver and communicate results to project teams to enable decision making;
• Manage interactions with external CROs to ensure high quality and on-time execution of DMPK studies;
• Maintain complete and timely data archiving;
• Write and review relevant sections of regulatory documents

Requirements

• PhD., Pharm. D. or equivalent training in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, or related disciplines, with 10 years of relevant experience in the bio/pharmaceutical industry or relevant CROs;
• In-depth understanding and strategic application of in vitro and in vivo ADME assays, methods and models;
• Direct hands-on experience and troubleshooting skills in in vitro and in vivo DMPK studies, including PK and PK/PD analyses, quantitative and qualitative LC-MS analysis, in vitro and in vivo biotransformation and human PK and drug interaction predictions is a plus;
• Expertise in managing CROs and sound knowledge of regulatory guidelines on bioanalysis, GLP practice and DDIs;
• Proficiency in Phoenix WinNonlin (classic WNL and PHX Model), or similar systems;
• Ability to develop user-specified mathematical models highly desired;
• Strong analytical, organizational and communication skills, and a consummate team player

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary

The Associate Director/Director of Business Development and Alliance Management will be instrumental in the strategic planning and execution of key Accent partnerships, including its foundational multi-program partnership with AstraZeneca, and critical portfolio strategy and business development initiatives. This highly visible, highly collaborative role will work broadly across the organization and cross-functionally with internal and external stakeholders.  Reporting to the Vice President, Head of Business Development, the Associate Director/Director of Business Development and Alliance Management will be responsible for all aspects of Alliance Management and for effectively communicating plans and partnership objectives to key stakeholders and executive management, and will be essential in contributing to key business development strategy and transactions and portfolio planning initiatives.

Responsibilities

• Perform all aspects of Alliance Management, including scheduling, developing agendas, drafting minutes, actions, and follow-up; as well as manage, as needed, Joint Steering Committee and Joint Project Team activities, with oversight over partnership activity timelines, budgets, etc.;
• Execute on Business Development initiatives, including business development strategy assessments, external partner outreach, negotiation and transactions, as well as portfolio strategy initiatives, including new product strategy analyses for the Accent pipeline;
• Develop and maintain exceptional business and scientific relationships with key internal and external stakeholders, working to gain consensus across organizations and striving to meet partnership goals and objectives;
• Leverage input from all critical organizational functions to create integrated plans for alliances that define goals, milestones, decision points, critical paths, financial assumptions and tracking, timelines, and alternative scenarios;
• Serve as a key point person for program team members on project-related communication, proactive issue identification and risk-mitigation;
• Drive process, with legal representatives, to draft or amend contracts or execute supplementary agreements, as needed, for collaborations;
• Conduct periodic partnership performance assessments with key stakeholders and implement solutions or improvements to optimize alliance performance and to maintain strong working relationships;
• Serve as an ambassador for Business Development and Alliance Management within the company

Requirements

• BS/BA in life sciences or related area (MBA/MA or PhD preferred) with five or more years of biotech and/or pharmaceutical industry experience;
• Significant understanding of the pharmaceutical research and development process and the regulatory process by which drug products are filed and approved;
• Comfort interpreting and managing deliverables under collaboration contracts;
• Excellent project management skills, including ability to coordinate cross-functional teams, meet deadlines, and manage collaborations across multiple programs and anticipate and resolve issues;
• Strong interpersonal and communication skills, including ability to clearly articulate complex issues and to engage with external parties for business development efforts;
• Excellent time management and organizational skills, demonstrating an ability to work independently, meet deadlines and prioritize work effectively;
• Ability to work effectively and congenially in a team setting with a collaborative mindset, consensus-building disposition, and culture-focus;
• Strong problem-solving, analytical skills, and excellent business judgment;
• Demonstrated self-starter mentality with a flexible approach to learning and taking on new challenges;
• Comfortable working in fast-paced, evolving, high-growth environment;
• Strong character, sense of humor, work ethic, detail-orientation, and results-driven outlook

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

As a key member of the Operations team reporting to the Chief Financial Officer, the Director, Human Resources will be essential in driving HR strategy, championing employee engagement, growth and development and delivering core HR functions, including HR planning and management, recruiting and retention, organizational learning and development, compensation and benefits, performance management, employee engagement and communications, and organizational structure and design.

 Responsibilities:

• Serve as a visible, involved and engaged leader to employees throughout the organization;
• Provide thought leadership on organizational and people-related strategy and execution to ensure a high-performing, engaged workforce;
• Identify, prioritize, design and implement HR programs and solutions that support employees and business objectives;
• Work with management of all levels on a variety of HR and business-related issues, both strategic and operational;
• Partner with the executive team and senior management to align the organizational structure, practices and communication with the Company’s strategy and culture;
• Provide human resources technical advice, guidance, knowledge and leadership to others within the organization;
• Lead efforts to prioritize employee engagement, growth and development in both group and 1:1 settings;
• Oversee and guide talent acquisition efforts;
• Lead organizational development efforts, including: management training, leadership development, performance review process, onboarding and interview training;
• Develop progressive and proactive compensation and benefits programs to attract prospective employees and motivate, incent, reward and retain existing employees in a manner that fosters high performance;
• Design programs to support a diverse and inclusive culture through hiring, promoting and rewards initiatives;
• Evolve HR infrastructure to a best-in-class function;
• Oversee HR related topics and initiatives for presentation to the Board of Directors and Compensation Committee

Qualifications and skills:

• Outstanding communication and listening skills;
• Demonstrated ability to build relationships and establish rapport with all levels of the organization, as well as influence positive behaviors and values throughout an organization;
• Strong background in designing and implementing organizational structures, strategic hiring and selection, employee and organizational development, compensation philosophy and total compensation programs;
• Ability to coach and counsel at all levels;
• 10+ years of progressively responsible experience in HR management, preferably in a combination of public and entrepreneurial environments;
• Experience in pharmaceutical, biotech or other life science companies is preferred

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

As a key member of the Biology team, the Scientist, Biology will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of RNA modification in human disease and progress the Accent pipeline.

Responsibilities:

• Independently design and execute experiments focused on the identification and validation of new RNA-modifying drug targets;
• Act as a key member of a cross-functional project team, working collaboratively to progress targets through the Accent pipeline;
• Participate in the creation of biology strategy for novel targets;
• Proactively review literature to bring in newest scientific findings, ideas, and methods/technologies for discovery research;
• Interpret, summarize and present research findings to project teams and Accent leadership

Qualifications:

• A PhD in Molecular Biology, Cancer Biology, or a related field plus at least 2 years post-degree experience; or a minimum of 8 years of industry experience with BS/MS
• Extensive experience in mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR, microscopy, flow cytometry);
• Knowledge of cancer biology and related signaling-pathways, and ability to critically evaluate relevant literature;
• Capability to work within a dynamic matrix environment, with strong contribution to project progression;
• Excellent organizational and communication skills;
• Experience working with and managing projects at CROs a plus

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

As a key member of the Protein and Structural Sciences team, the Senior / Principal Scientist will play a critical and influential role in the application of biophysical methods in drug discovery. Reporting to the Director of Protein & Structural Sciences, the Senior / Principal Scientist will apply biophysical methods to understand small molecule-protein interactions and work cross-functionally with teams of internal and external scientists to utilize this expertise to provide insights that will advance Accent’s drug discovery programs.

Responsibilities:

• Design, execute, and analyze key Surface Plasmon Resonance (SPR) experiments for small molecule compound screening with a high level of independence to support hit finding, lead optimization and mechanism of inhibition studies;
• Maintain internal databases with latest results and contribute to optimization of LIMS systems for biophysical data;
• Effectively communicate biophysical information and results to a variety of audiences in multiple settings, including project teams and company management;
• Oversee activities at partner CROs producing biophysical data;
• Establish and manage an internal SPR facility at Accent

Qualifications:

• A PhD or equivalent experience in Biophysics, Biochemistry, Bioanalytical Chemistry or a closely related field;
• 4+ years of experience in industry with 2+ years laboratory experience using SPR spectroscopy, experience with Biacore platforms preferred;
• Extensive knowledge and experience with SPR and other biophysical techniques (including DSF, ITC, MST and NMR), with the ability to communicate complex information to a broad audience
• Proficiency in operating and maintaining SPR systems and associated data processing packages;
• Demonstrated commitment to innovation and scientific rigor across multiple protein targets and superfamilies;
• Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude;
• Experience with outsourcing preferred;
• Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude, motivated by a desire to create the novel cancer therapeutics and the vision to offer cancer patients novel therapies that extend and improve their lives

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

As a key member of the Biology team, this Senior or Principal Research Associate will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of RNA modification in human disease, and progress the Accent pipeline.

Responsibilities:

• Execute cell and molecular biology studies to investigate the role of novel RNA modification pathways in human disease;
• Assist with the development of cell-based assays to be used in support of medicinal chemistry efforts and structure activity relationship assessment;
• Maintain good written records of laboratory procedures, results and conclusions;
• Perform and report interim analysis of accumulated data to project teams and Accent leadership;
• Assist in the development of and compliance with all Accent policies and operational guidelines;
• Participate in various aspects of small company capability building

Qualifications:

• BS/MS in Biology or related field with a minimum of 3+ years relevant industry experience or the equivalent expertise;
• Proficiency with mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
• Excellent organizational and communication skills;
• Ability to design and execute experiments, analyze and document results as part of a fast-paced research team

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.