+-Manager / Senior Manager, Informatics
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
As a key member of the Operations team reporting to the Senior Manager of Research Operations, the Informatics Manager will manage, support, and develop our research informatics and data management platforms. The Informatics Manager will actively collaborate cross-functionally to lead the development and evolution of the informatics platform to support Accent’s continued growth.
Responsibilities:
- Oversee informatics infrastructure by managing, upgrading, and coordinating service across all of Accent’s SaaS (Software as a Service) platforms;
- Design, implement and document system configurations for new and existing informatics system implementation, including sample management, results analysis, lab workflow, release & stability management, electronic lab notebooks (ELN) etc.;
- Collaborate with key internal and external stakeholders, including internal scientists in the DMPK, Biology, Molecular Discovery, and Chemistry teams to support and enhance informatics platforms;
- Coordinate software needs of internal groups with SaaS providers and work with SaaS providers in future product design and improvement (e.g., automation of processes such as data capture and registration);
- Negotiate and coordinate the renewal of SaaS provider and consultant contracts annually;
- Support weekly registration activities of compounds and biologics;
- Conduct system testing prior to new feature releases; coordinate new user training and host quarterly informatics user group sessions;
- Assist users with creating new protocols, assays, dashboards, queries, etc. in the ELN and other data analysis/visualization platforms;
- Assist with system support, maintenance, and administration of lab equipment, such as:
- Robotic liquid handlers from TECAN and Agilent Technologies
- Readers from PerkinElmer, BMG Labtech, etc.
Qualifications:
- M.S. with at least 3+ years of industry experience in research informatics, data management, data engineering; or Bachelor’s degree with 4+ years of experience;
- Experience in implementing a major, commercial SaaS LIMS product preferred;
- Working knowledge of biology, biophysics, chemistry, and preclinical data;
- Working knowledge of Windows and Linux operating systems;
- Experience with REST API and Amazon Web Services (AWS) Research compute environment is preferred;
- Excellent organizational skills and ability to multi-task in an extremely fast-paced environment;
- Working knowledge of AGILE principles is a plus;
- Strong communication, interpersonal and collaboration skills in order to successfully partner with internal and external stakeholders;
- Solid analytical and problem-solving abilities
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Director, Intellectual Property
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017 and named as one of Fortune’s 50 Top Ten Workplaces in Healthcare and Biopharma and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly-collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
Reporting to the Chief Financial Officer, the Director of Intellectual Property will play a key strategic role in architecting and managing the Company’s intellectual property strategy and portfolio. This key role will direct and oversee all intellectual property matters, working with outside counsel and internal team members to strategically evaluate intellectual property opportunities; prepare, review, file, and prosecute patent applications; and monitor patent, regulatory and competitive landscapes. The ideal candidate will be a trusted advisor and business partner with the ability to identify and align strategic opportunities to critical business objectives.
Responsibilities:
- Develop and execute creative and thoughtful strategies to protect the company’s intellectual property;
- Work closely with R&D teams to build strong patent portfolios around key assets to ensure long-term competitive advantage by identifying and evaluating new inventions, conducting prior art searches, managing new and existing patent portfolios, and responding to administrative challenges instituted by third parties;
- Identify, monitor and analyze competitive intellectual property and potential freedom-to-operate matters;
- Manage outside counsel on worldwide patent prosecution and maintenance and work with outside counsel to draft and prosecute the company’s patent applications;
- Review proposed publications and presentations for potential disclosure issues;
- Provide advice and cross-functional support for R&D, business development, alliance management, project teams and other functional areas through all phases of research and development;
- Working with management, prepare, negotiate, and review contracts and agreements;
- Support IP due diligence and agreement review/negotiation related to partnering activities;
- Educate and advise colleagues on IP processes and best practices;
- Work with the executive leadership team to implement and administer IP policies and best practices
Qualifications and skills:
- 5+ years of experience practicing intellectual property law, with an emphasis on small molecule patent prosecution, at a large law firm and/or in-house legal department;
- Registered to practice before the U.S. Patent and Trademark Office;
- J.D. from an accredited law school;
- Thorough understanding of U.S. patent law and familiar with foreign patent laws in major countries;
- Excellent interpersonal, communication and presentation skills, including ability to communicate complex issues clearly and succinctly;
- Ability to think strategically with a broad perspective;
- Strong organizational skills, including careful attention to detail and ability to manage and prioritize multiple matters simultaneously and to respond to rapidly shifting priorities in ambiguous or challenging situations;
- Ability to work collaboratively as a business partner and to recognize and respond quickly, clearly and pragmatically to urgent situations and opportunities;
- Ph.D. or other advanced degree in organic chemistry or chemical sciences preferred
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
+-Associate Director / Director, Biology
Company Overview:
Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Founded in 2017, named as one of Fortune’s Top Ten Workplaces in Healthcare and Biopharma in 2020, and one of Fierce Biotech’s Fierce15 in 2020, Accent is building a highly collaborative team of experienced high-caliber drug developers to develop life-changing therapies for patients.
Position Summary:
Accent has built a robust portfolio of exciting drug targets for Oncology and is seeking an Associate Director/Director of Innate Immunity to lead multiple ongoing small-molecule drug discovery programs in this space. This individual will apply deep knowledge of cancer biology and innate immunity to execute scientifically rigorous strategies to inform drug discovery and programmatic decision making. This position will lead biology activities for these programs to ensure relevant and high-quality data is generated and insights used to drive discovery and clinical strategy forward, and work collaboratively with project teams to set overall objectives to achieve lead and candidate milestones through to clinical development.
The successful candidate will use internal resources and CRO capabilities, as well as collaborate with cross-functional teams, to progress Accent programs. This position reports to the Vice President of Biology and will also contribute to overall Research strategy as part of the Biology and Translational Medicine Leadership Team.
Responsibilities:
- Provide scientific leadership for an internal team of biologists to find creative solutions to challenges that enable program progression from target validation through development candidate selection
- Train and oversee work of scientists in-house and at CROs
- Actively lead and/or participate as part of cross-functional project teams to advance pipeline projects
- Evaluate, interpret, and document scientific results and communicate findings and recommendations internally and with external collaborators
- Analysis of proprietary and public profiling data to generate and test hypotheses for patient selection
- Support external and internal evaluation of novel areas of disease/target biology to nominate therapeutic targets to our portfolio
- Provide mechanistic and translational immunology insights based on deep understanding of literature and applied experiential knowledge
- Effectively communicate complex information to internal and external audiences
- Establish relationships, manage contracts, and oversee activities at partner CROs
Qualifications and skills:
- PhD in Immuno-oncology, Biology, Immunology, or a closely related field plus at least 10 years of industry experience or the equivalent expertise
- Experience managing and mentoring multiple direct reports
- Deep expertise in target identification and target validation, target biology elucidation, and biomarker discovery
- Demonstrated track record driving collaborative approaches in drug discovery with internal as well as external partners.
- Experience with outsourcing desired
- Ability to prioritize, present in an organized and concise manner, manage time efficiently, and implement creative solutions to meet program needs.
- A track record of innovation and scientific rigor as evidenced by a strong publication record
- Demonstrated leadership on project teams (Project or Department/Discipline lead) and/or in matrixed organizations is desired
- Ability to work in a fast-paced, team-driven environment with a collaborative and proactive attitude, motivated by a desire to offer cancer patients novel therapies that extend and improve their lives
Position: Full-Time, Exempt
Location: Lexington, MA
Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
To apply, please send your resume to HR@accenttx.com.
Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.
