Position Summary:

As a key member of the Biology team, the Scientist or Senior Scientist will join a dynamic, enthusiastic, highly interdisciplinary and collaborative team to elucidate the role of RNA modification in human disease and progress the Accent pipeline.

Responsibilities:

• Independently design and execute experiments focused on the identification and validation of new RNA-modifying drug targets;
• Act as a key member of a cross-functional project team working collaboratively to progress targets through the Accent pipeline;
• Participate in the creation of biology strategy for novel targets;
• Proactively review literature to bring in newest scientific findings, ideas, and methods/technologies for discovery research; and
• Interpret, summarize and present research findings to project teams and Accent leadership

Qualifications:

• A PhD in Molecular Biology, Cancer Biology, or a related field plus at least 2 years post-degree experience; or a minimum of 8 years of industry experience with BS/MS
• Extensive experience in mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
• Knowledge of cancer biology and related signaling-pathways, and ability to critically evaluate relevant literature;
• Capability to work within a dynamic matrix environment, with strong contribution to project progression;
• Excellent organizational and communication skills;
• Experience working with and managing projects at CROs a plus

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

As a senior medicinal chemist reporting to the Head of Chemistry, this person will implement the medicinal chemistry strategy while collaborating with a cross-functional team of scientists and lead a team of external synthetic chemistry resources to progress multiple drug discovery programs.

Responsibilities:

• Co-lead interdisciplinary project teams and work with a team of scientists to progress projects from target selection and validation through candidate selection;
• Design and oversee synthesis of novel chemical entities aimed to optimize biochemical and cell potency, selectivity, pharmacokinetic properties and in vivo efficacy;
• Contribute to execution of IP strategy in collaboration with internal and external intellectual property attorneys;
• Oversee activities at partner CROs

Qualifications and skills:

• Ph.D. in synthetic organic chemistry or medicinal chemistry with a minimum of 5 years of medicinal chemistry experience in the pharmaceutical industry;
• Hands-on experience in successfully designing and synthesizing novel small molecule therapies;
• Extensive knowledge in the current practice and literature of synthetic and medicinal chemistry;
• Strong understanding of structure-based design, physicochemical properties, and DMPK;
• Experience with computational software, electronic notebooks and LIMS;
• Experience in co-leading discovery projects;
• Effective oral and written communication with peers and people in other functional areas;
• Ability to work independently and in a dynamic team environment;
• Knowledge and experience of fragment approaches and/or novel protein targets are desirable;
• Experience in screening and hit validation activities for enzymatic and binding assays is desirable;
• Experience in outsourcing and managing CROs is a plus;
• Experience in oncology is a plus

 Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Position Summary:

As a key member of the Biology team, this Senior or Principal Research Associate will join a dynamic, enthusiastic, highly interdisciplinary, and collaborative team to elucidate the role of RNA modification in human disease, and progress the Accent pipeline.

Responsibilities:

• Execute cell and molecular biology studies to investigate the role of novel RNA modification pathways in human disease;
• Assist with the development of cell-based assays to be used in support of medicinal chemistry efforts and structure activity relationship assessment;
• Maintain good written records of laboratory procedures, results and conclusions;
• Perform and report interim analysis of accumulated data to project teams and Accent leadership;
• Assist in the development of and compliance with all Accent policies and operational guidelines;
• Participate in various aspects of small company capability building

Qualifications:

• BS/MS in Biology or related field with a minimum of 3+ years relevant industry experience or the equivalent expertise;
• Proficiency with mammalian tissue culture (including si/shRNA, CRISPR, and lentivirus) and modern molecular biology techniques (Western blotting, RT-qPCR);
• Excellent organizational and communication skills;
• Ability to design and execute experiments, analyze and document results as part of a fast-paced research team

Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.