Position Summary:

As a senior medicinal chemist reporting to the Head of Chemistry, this person will implement the medicinal chemistry strategy while collaborating with a cross-functional team of scientists and lead a team of external synthetic chemistry resources to progress multiple drug discovery programs.

Responsibilities:

• Co-lead interdisciplinary project teams and work with a team of scientists to progress projects from target selection and validation through candidate selection;
• Design and oversee synthesis of novel chemical entities aimed to optimize biochemical and cell potency, selectivity, pharmacokinetic properties and in vivo efficacy;
• Contribute to execution of IP strategy in collaboration with internal and external intellectual property attorneys;
• Oversee activities at partner CROs

Qualifications and skills:

• Ph.D. in synthetic organic chemistry or medicinal chemistry with a minimum of 7 years of medicinal chemistry experience in the pharmaceutical industry;
• Hands-on experience in successfully designing and synthesizing novel small molecule therapies;
• Extensive knowledge in the current practice and literature of synthetic and medicinal chemistry;
• Strong understanding of structure-based design, physicochemical properties, and DMPK;
• Experience with computational software, electronic notebooks and LIMS;
• Experience in co-leading discovery projects;
• Effective oral and written communication with peers and people in other functional areas;
• Ability to work independently and in a dynamic team environment;
• Knowledge and experience of fragment approaches and/or novel protein targets are desirable;
• Experience in screening and hit validation activities for enzymatic and binding assays is desirable;
• Experience in outsourcing and managing CROs is a plus;
• Experience in oncology is a plus

 Position:  Full-Time, Exempt

Location:  Lexington, MA

Accent values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Accent will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

To apply, please send your resume to HR@accenttx.com.

Note to Third Party Staffing Agencies:  Please do not forward any agency resumes. Accent Therapeutics is not responsible for any fees related to resumes that are unsolicited.